Current and Future Immunosuppressive Therapies Following Transplantation

1. Front Matter

   Pages i-ix

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. The History of Immunosuppression for Organ Transplantation

      • Johnny C. Hong, Barry D. Kahan

      Pages 3-17

   3. Clinical Trials in Transplant Immunosuppression: What Have We Learned?

      • P. Schnuelle, F. J. van der Woude

      Pages 19-40

3. Pharmacological Immunosuppression

   1. Front Matter

      Pages 41-41

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   2. Pharmacologic Monitoring of Immunosuppressive Drugs

      • Flavio Gaspari, Norberto Perico, Giuseppe Remuzzi

      Pages 43-59

   3. Use of Corticosteroids in Kidney Transplantion

      • Donald E. Hricik

      Pages 61-84

   4. Mycophenolate Mofetil and Azathioprine

      • John D. Pirsch, Elias David-Neto

      Pages 85-110

   5. Cyclosporine Formulations

      • Venkataraman Ramanathan, J. Harold Helderman

      Pages 111-121

   6. Tacrolimus

      • Ron Shapiro

      Pages 123-142

   7. Sirolimus

      • Barry D. Kahan

      Pages 143-163

   8. New Agents on the Horizon

      • Jochen Klupp, Randall E. Morris

      Pages 165-183

4. Biologicals

   1. Front Matter

      Pages 185-185

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   2. Why To We Need Induction Therapy?

      • John Vella, John Neylan

      Pages 187-204

   3. Ponyclonal Antilymphocyte Antibodies

      • Paul Morrissey, Anthony P. Monaco

      Pages 205-220

   4. Monoclonal Antibody Targeting of the T Cell Receptor Complex

      • Lucienne Chatenoud

      Pages 221-234

   5. Monoclonal Antibody Targeting of the Il-2R Complex

      • Flavio G. Vincenti

      Pages 235-248

   6. Monoclonal Antibody Targeting of Adhesion Molecules

      • Markus H. Frank, David M. Briscoe

      Pages 249-263

   7. Costimulation Blockade

      • Roy D. Bloom, Laurence A. Turka

      Pages 265-277

   8. Immunomodulatory Function of MHC Peptides

      • Barbara Murphy, Alan Krensky

      Pages 279-292

This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.

• T cell
• clinical trial
• gene therapy
• immunology
• immunosuppression
• kidney
• organ
• organ transplantation
• transplantation
• hepatology

• Harvard Medical School, Boston, USA

  Mohamed H. Sayegh

• Mario Negri Institute for Pharmacological Research, Bergamo, Italy

  Giuseppe Remuzzi

Policies and ethics