Brain Metastasis

1. Front Matter

   Pages i-xxxi

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2. Basic Aspects of Brain Metastasis

   1. Front Matter

      Pages 1-1

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   2. Brain Metastases

      • Jerome B. Posner

      Pages 2-29

   3. The Cell Periphery and Metastasis

      • Leonard Weiss

      Pages 30-49

   4. Experimental Brain Metastasis

      • Kenneth W. Brunson, Garth L. Nicolson

      Pages 50-65

   5. The Role of Brain Metastases in Cascade Processes: Implications for Research and Clinical Management

      • Irwin D. J. Bross

      Pages 66-80

   6. Arrest and Extravasation of Cancer Cells with Special Reference to Brain Metastases and the Microinjury Hypothesis

      • B. A. Warren

      Pages 81-99

   7. Quantitative Aspects of Osmotic Opening of the Blood-Brain Barrier

      • Stanley I. Rapoport

      Pages 100-114

   8. Brain Tumor Microvasculature

      • Nicholas A. Vick

      Pages 115-133

   9. A Model for Brain Metastasis

      • William R. Shapiro

      Pages 134-145

   10. Pharmacokinetics and Metastatic Brain Tumor Chemotherapy

       • Ronald G. Blasberg

       Pages 146-164

   11. Human Cancer Immunology

       • Herbert F. Oettgen, Hiroshi Shiku, Toshitada Takahashi, Thomas Carey, Lois Resnick, Ryuzo Ueda et al.

       Pages 165-185

3. The Diagnosis of Brain Metastases

   1. Front Matter

      Pages 187-187

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   2. Clinical Manifestations of Brain Metastasis

      • Jerome B. Posner

      Pages 189-207

   3. Computed Tomography of Metastatic Disease of the Brain

      • Michael D. F. Deck

      Pages 208-241

   4. Radionuclide Imaging of Cancer Metastases in the Brain

      • Richard S. Benua

      Pages 242-245

   5. Positron-Emission Tomography

      • Marcus E. Raichle

      Pages 246-253

4. The Treatment of Brain Metastasis

   1. Front Matter

      Pages 255-255

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   2. Analysis of the Benefit of Palliation of Brain Metastases

      • Stanley E. Order

      Pages 257-264

   3. The Memorial Hospital Experience

      • Florence Chu

      Pages 265-268

Of those people dying with cancer, many die as a result of metastases. In spite of this, a surprisingly small number of texts have been devoted to this clinically important topic. The present series of monographs originated in discussions, which convinced us of the need for texts on metasasis which would contain not only basic and clinical observations on human beings and where neces­ sary, on experimental animals but also discussions of the state of the art in diagnosis and therapy. In order to achieve this in-depth approach, for which publication was preceded by small workshops, it was necessary to impose limitations on the scope of the topic. Metastasis is therefore dis­ cussed by site, and the series is organized accordingly. The first volume in the series, Pulmonary Metastasis, was an expanded version of a Workshop held at Roswell Park Memorial Institute in 1977. This, the second volume, is based on a similar workshop on metastasis to the brain, held at the Memorial Sloan-Kettering Cancer Center in September, 1978. In organiz­ ing both the workshop and in editing this volume, we have been excep­ tionally fortunate to receive the generous cooperation of Dr. Jerome B. Posner, a practicing neurologic oncologist who has given freely of his ex­ pertise in this specialized field.

• Nervous System
• brain
• brain tumor
• carcinoma
• cell
• computed tomography (CT)
• hormones
• imaging
• metastasis
• metastatic disease
• neuropathology
• pathology
• tumor

• Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, USA

  Leonard Weiss

• Department of Radiation Therapy, Southern California Permanente Medical Group, Los Angeles, USA

  Harvey A. Gilbert

• Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, USA

  Jerome B. Posner

Policies and ethics