Overview
- Authors:
-
-
Alois Čihák
-
Institute of Organic Chemistry and Biochemistry, Czechoslovakia Academy of Sciences Prague, Czechoslovakia
-
Werner Reutter
-
Institut für Molekularbiologie und Biochemie der Freien Universität, Berlin, Germany
Access this book
Other ways to access
Table of contents (9 chapters)
-
-
Orotic Acid: Synthesis, Biochemical Aspects and Physiological Role
-
-
- Alois Čihák, Werner Reutter
Pages 3-6
-
- Alois Čihák, Werner Reutter
Pages 7-13
-
- Alois Čihák, Werner Reutter
Pages 14-17
-
- Alois Čihák, Werner Reutter
Pages 18-22
-
- Alois Čihák, Werner Reutter
Pages 23-25
-
- Alois Čihák, Werner Reutter
Pages 26-30
-
- Alois Čihák, Werner Reutter
Pages 31-34
-
- Alois Čihák, Werner Reutter
Pages 35-40
-
- Alois Čihák, Werner Reutter
Pages 41-45
-
About this book
This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic.
Authors and Affiliations
-
Institute of Organic Chemistry and Biochemistry, Czechoslovakia Academy of Sciences Prague, Czechoslovakia
Alois Čihák
-
Institut für Molekularbiologie und Biochemie der Freien Universität, Berlin, Germany
Werner Reutter
