Midkine: From Embryogenesis to Pathogenesis and Therapy

1. Front Matter

   Pages i-ix

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2. General Aspects of Midkine

   1. Front Matter

      Pages 1-1

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3. GENERAL ASPECTS OF MIDKINE

   1. General Information on Midkine

      • Takashi Muramatsu

      Pages 3-13

   2. The Role of Midkine in Neural Development and Patterning

      • Sheng Yao, Christoph Winkler

      Pages 15-28

   3. Midkine: A Player in Innate Immunity

      • Sara L. Nordin, Arne Egesten

      Pages 29-39

   4. Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition

      • Yiping Huang, Edward A. Ratovitski

      Pages 41-52

   5. Immunochemical Methods for the Detection of Midkine in Samples of Human Origin

      • Stefan Sommerschuh, Michael Kirchner, Nicole Gliese

      Pages 53-67

   6. Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review

      • Malgorzata Krzystek-Korpacka, Malgorzata Matusiewicz

      Pages 69-85

4. Midkine and Inflammation

   1. Front Matter

      Pages 87-87

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5. MIDKINE AND INFLAMMATION

   1. Midkine in Inflammation and Inflammatory Diseases

      • Nuray Yazıhan, Mehtap Kacar Kocak, Ethem Akcıl

      Pages 89-101

   2. Rheumatoid Arthritis and Midkine

      • Hisako Muramatsu, Kiyoko Maruyama, Naoki Ishiguro

      Pages 103-109

6. Midkine and the Cardiovascular System

   1. Front Matter

      Pages 111-111

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7. MIDKINE AND THE CARDIOVASCULAR SYSTEM

   1. Midkine and Heart Failure

      • Mitsuru Horiba, Kenji Kadomatsu

      Pages 113-124

   2. Vascular Restenosis and Midkine

      • Kenji Kadomatsu

      Pages 125-130

   3. The Potential of MK Through the Renin-Angiotensin System

      • Tomoki Kosugi, Kenji Kadomatsu

      Pages 131-140

8. Midkine and the Nervous System

   1. Front Matter

      Pages 141-141

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9. MIDKINE AND THE NERVOUS SYSTEM

   1. Midkine and Multiple Sclerosis

      • Hideyuki Takeuchi

      Pages 143-151

   2. Midkine Gene Transfer in Brain Infarction

      • Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita, Yasuhiro Kumai

      Pages 153-163

   3. Midkine in Psychiatric and Neurodegenerative Diseases

      • Eiji Shimizu, Daisuke Matsuzawa

      Pages 165-170

10. Midkine and the Urogenital System, Reproduction and Aging

    1. Front Matter

       Pages 171-171

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Carl Edward Sagan’s (1934-1996) one of the famous quotation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as botha pathologic factor and therapeutic agent.

• Development and reproduction
• Disease
• Midkine
• Survival and resistance
• Therapy

• Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Istanbul, Turkey

  Mine Ergüven

• , Department of Health Science, Aichi Gakuin University, Nisshin, Japan

  Takashi Muramatsu

• , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Istanbul, Turkey

  Ayhan Bilir

Policies and ethics