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The Renin-Angiotensin System: Current Research Progress in The Pancreas

The RAS in the Pancreas

  • Book
  • © 2010

Overview

Authors:
  1. Po Sing Leung

    1. , Faculty of Medicine, The Chinese Univers, School of Biomedical Sciences, Hong Kong, China, People's Republic

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  • A topical, timely and focussed book in the field
  • A book written by a single author who contributes significantly to the field
  • A selected compilation of TEN selected chapters that critically appraise the contemporary research advance in the field
  • A critical review that spans the spectrum from basic science to the bedside in the field
  • A concise and comprehensive book that is tailor made for specialists and non-specialists as well as for newcomers in the field

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 690)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xvi
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  2. The Pancreas

    1. Front Matter

      Pages 1-1
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    2. Overview of the Pancreas

      • Po Sing Leung
      Pages 3-12

    3. Physiology of the Pancreas

      • Po Sing Leung
      Pages 13-27

    4. Common Pancreatic Disease

      • Po Sing Leung
      Pages 29-51

  3. The Renin-Angiotensin System (RAS)

    1. Front Matter

      Pages 53-53
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    2. Circulating RAS

      • Po Sing Leung
      Pages 55-68

    3. Local RAS

      • Po Sing Leung
      Pages 69-87

    4. Pancreatic RAS

      • Po Sing Leung
      Pages 89-105

  4. Research Progress Of The Ras In Pancreas

    1. Front Matter

      Pages 107-107
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    2. Basic Techniques for Pancreatic Research

      • Po Sing Leung
      Pages 109-130

    3. Current Research of the RAS in Diabetes Mellitus

      • Po Sing Leung
      Pages 131-153

    4. Current Research Concerning the RAS in Pancreatic Stem Cells

      • Po Sing Leung
      Pages 155-177

    5. Current Research of the RAS in Pancreatitis and Pancreatic Cancer

      • Po Sing Leung
      Pages 179-199

  5. Back Matter

    Pages 201-207
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Keywords

About this book

The human pancreas has vital roles in the regulation of glucose homeostasis and digestion and its dysfunction leads to pancreatic disease as diabetes and pancreatitis. Recent researches have highlighted the novel roles of a local renin-angiotensin system (RAS) in the pancreas and its clinical relevances; its inapprporiate activation leads to pancreatic endocrine and exocrine disease, notably type 2 diabetes. As such, manipulation of the overactive RAS may improve pancreatic islet cell function, cell mass and insulin sensitivity, as well as enhancing the growth and differentiation of pancreatic stem cells. Blockade of the RAS may be protective against pancreatitis and pancreatic cancer. The research outcome of current progress on the RAS in the pancreas should provide an alternative approach to preventing and treating, as well as curing pancreatic disease. This book discusses the progress of research on the renin-angiotensin system in the pancreas from the science to the bedside, providing a timely review of this expanding area. It consists of ten interrelated chapters covering subjects as: – Structure, physiology and disease of the pancreas – Biochemistry and physiology of the pancreatic renin-angiotensin system – RAS in diabetes, stem cells and pancreatitis This book is of special value to basic and clinical scientists, clinicians, graduate students, as well as novices in this field.  

Authors and Affiliations

  • , Faculty of Medicine, The Chinese Univers, School of Biomedical Sciences, Hong Kong, China, People's Republic

    Po Sing Leung

Bibliographic Information

  • Book Title: The Renin-Angiotensin System: Current Research Progress in The Pancreas

  • Book Subtitle: The RAS in the Pancreas

  • Authors: Po Sing Leung

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-90-481-9060-7

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2010

  • Hardcover ISBN: 978-90-481-9059-1Published: 20 September 2010

  • Softcover ISBN: 978-94-007-3332-9Published: 06 November 2012

  • eBook ISBN: 978-90-481-9060-7Published: 12 August 2010

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 208

  • Topics: Biomedicine general, Gastroenterology, Diabetes, Human Physiology

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