Apoptosis in Carcinogenesis and Chemotherapy

1. Front Matter

   Pages I-XXII

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2. Apoptotic Signaling Pathway and Resistance to Apoptosis in Breast Cancer Stem Cells

   • Prasanthi Karna, Lily Yang

   Pages 1-23

3. Anti-Cancer Strategy of Transitional Cell Carcinoma of Bladder Based on Induction of Different Types of Programmed Cell Deaths

   • Jose A. Karam, Jer-Tsong Hsieh

   Pages 25-50

4. Apoptosis in Carcinogenesis and Chemoherapy of the Uterine Cervix

   • Sakari Hietanen

   Pages 51-73

5. Apoptosis in Colorectal Tumorigenesis and Chemotherapy

   • Shi Yu Yang, Kevin M. Sales, Marc C. Winslet

   Pages 75-109

6. Apoptosis in Cutaneous Melanoma

   • Michael B. Nicholl, Dave S.B. Hoon

   Pages 111-125

7. Apoptosis in Carcinogenesis and Chemotherapy – Esophageal Cancer

   • Yan Li, Robert C.G. Martin

   Pages 127-156

8. Molecular Targets in Gastric Cancer and Apoptosis

   • Elizabeth K. Balcer-Kubiczek, Michael C. Garofalo

   Pages 157-192

9. Apoptosis and the Tumor Microenvironment in Hematologic Malignancies

   • Danielle N. Yarde, Jianguo Tao

   Pages 193-218

10. Bcl-2 Family Members in Hepatocellular Carcinoma (HCC) – Mechanisms and Therapeutic Potentials

    • Shihong Ma, George G. Chen, Paul B.S. Lai

    Pages 219-235

11. Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin

    • Maximino Redondo, Rafael Fùnez, Francisco Esteban

    Pages 237-249

12. Cyclooxygenase 2 and its Metabolites: Implications for Lung Cancer Therapy

    • Kin Chung Leung, George G. Chen

    Pages 251-272

13. Roles of Negative and Positive Growth Regulators in Nasopharyngeal Carcinoma

    • Mong-Hong Lee, Huiling Yang, Ruiying Zhao, Sai-Ching J. Yeung

    Pages 273-294

14. Cellular Signaling Mechanisms in Pancreatic Apoptosis

    • Nawab Ali, Stewart MacLeod, R. Jean Hine, Parimal Chowdhury

    Pages 295-325

15. Strategies to Circumvent Resistance to Apoptosis in Prostate Cancer Cells by Targeted Necrosis

    • Richard D. Dinnen, Daniel P. Petrylak, Robert L. Fine

    Pages 327-346

16. Carcinogenesis and Therapeutic Strategies for Thyroid Cancer

    • Zhi-Min Liu, George G. Chen

    Pages 347-374

17. Back Matter

    Pages 375-384

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Although research on carcinogenesis has focused more on cellular proliferation than on cell death, yet understanding the mechanism of apoptosis may have important implications for cancer therapy. This book brings together experts from around the world who will discuss the common cancers encountered in clinical practice in the laboratory setting. During the induction of these common cancers, the role of apoptosis in cellular and molecular changes is emphasized, critically highlighting possible anti-cancer strategies. For those who are interested in carcinogenesis and for those who are seeking new approaches to anti-cancer therapy, this book is an important reference. It serves not only as a reference of the current understanding of apoptosis in common cancers but also an important bridge between the laboratory and clinical practice. The editors and contributors are to be congratulated in bringing together an important pool of up-to-date knowledge to light and further our interest in this exciting and expanding ?eld. Arthur K. C. Li Emeritus Professor of Surgery The Chinese University of Hong Kong v Preface The role of apoptosis in cancer development and emerging treatment strategies has rapidly expanded over the past few years. The novel discovery in the apoptotic pa- ways and their relevant molecules provides us not only the knowledge how tumors develop but also the opportunity to design new therapeutic tools to prevent or inhibit the growth of tumors with minimal side-effects. Undoubtedly, understanding the events involved at a molecular level can permit the manipulation of apoptosis for therapeutic purposes.

• apoptosis
• cancer
• cancer therapy
• carcinogenesis
• carcinoma
• cell
• cell death
• chemotherapy
• melanoma
• programmed cell death
• prostate cancer
• resistance
• stem cells
• tumor
• tumorigenesis
• surgical oncology

• Department of Surgery Shatin, Chinese University of Hong Kong Prince of Wales Hospital, Shatin, Hong Kong/PR China

  George G. Chen, Paul B.S. Lai

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