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  • © 2008

Programmed Cell Death in Cancer Progression and Therapy

  • Up-to-date and comprehensive description of Molecular Mechanism of PCD in Cancer Progression and Therapy
  • Up-to-date and comprehensive information regarding the current therapeutic strategies that utilize PCD
  • Detailed indication of the utility of PCD in future cancer therapy
  • Chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 615)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiv
  2. Cell Death: History and Future

    • Zahra Zakeri, Richard A. Lockshin
    Pages 1-11
  3. Caspase Mechanisms

    • Guy S. Salvesen, Stefan J. Riedl
    Pages 13-23
  4. The Mitochondrial Death Pathway

    • Anas Chalah, Roya Khosravi-Far
    Pages 25-45
  5. Apoptotic Pathways in Tumor Progression and Therapy

    • Armelle Melet, Keli Song, Octavian Bucur, Zainab Jagani, Alexandra R. Grassian, Roya Khosravi-Far
    Pages 47-79
  6. Overcoming Resistance to Apoptosis in Cancer Therapy

    • Peter Hersey, Xu Dong Zhang, Nizar Mhaidat
    Pages 105-126
  7. Trail Receptors: Targets for Cancer Therapy

    • Robin C. Humphreys, Wendy Halpern
    Pages 127-158
  8. Regulation of Programmed Cell Death by the P53 Pathway

    • Kageaki Kuribayashi, Wafik S. El-Deiry
    Pages 201-221
  9. Regulation of Programmed Cell Death by NF-κB and its Role in Tumorigenesis and Therapy

    • Yongjun Fan, Jui Dutta, Nupur Gupta, Gaofeng Fan, Céline Gélinas
    Pages 223-250
  10. Targeting Proteasomes as Therapy in Multiple Myeloma

    • Dharminder Chauhan, Teru Hideshima, Kenneth C. Anderson
    Pages 251-260
  11. RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches

    • Derek M. Dykxhoorn, Dipanjan Chowdhury, Judy Lieberman
    Pages 299-329
  12. Cancer Stem Cells and Impaired Apoptosis

    • Zainab Jagani, Roya Khosravi-Far
    Pages 331-344
  13. Back Matter

    Pages 345-356

About this book

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeutics.

Reviews

From the reviews:

"Programmed cell death (PCD) is an intriguing term that was introduced by Richard Lockshin nearly 45 years ago. … this book is about PCD with intense focus on apoptosis and the exploitation of PCD for treating cancer. … All chapters are well edited and thoroughly referenced. The nicety of the book is the use of numerous color figures. In my opinion, both scientists and clinicians, experienced or beginning, will profit from a thoughtful reading of Programmed Cell Death in Cancer Progression and Therapy." (A. A. Philchenkov, Biochemistry (Moscow), Vol. 74 (4), 2009)

Authors and Affiliations

  • Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, USA

    Roya Khosravi-Far

  • Center for Advanced Biotechnology and Medicine; Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, USA

    Eileen White

  • Cancer Institute of New Jersey, New Brunswick, USA

    Eileen White

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access