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Brain Damage and Repair

From Molecular Research to Clinical Therapy

  • Book
  • © 2004

Overview

Editors:
  1. T. Herdegen

    1. Institute of Pharmacology, University of Kiel, Kiel, Germany

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  2. J. Delgado-García

    1. Department of Neurosciences, University Pablo de Olavide, Sevilla, Spain

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    You can also search for this editor in PubMed   Google Scholar

  • Aims at building a novel bridge from molecular research to clinical therapy
  • omprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowledge, apply it at the clinical level to provide a basis for novel therapeutic strategies
  • Is completed with chapters on imaging techniques, viral gene transfer or legal international handling of stem cell transfer and patents of DNA/proteins

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-xiv
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  2. The Vulnerable Neuron or Why Neurons Die

    1. The Aging Brain — the Burden of Life (?)

      • S. Hoyer, K. Plaschke
      Pages 1-22

    2. Gene Expression and Its Regulation in Neurons

      • L. Kaczmarek
      Pages 23-31

    3. Morphological Peculiarities of the Neuron

      • I. P. Johnson
      Pages 33-45

    4. Synaptic Plasticity: Hyperexcitability and Synaptic Silencing

      • L. Martínez-Millán, G. García del Caño, I. Gerrikagoitia
      Pages 47-59

    5. The Axonal Burden

      • H. Aldskogius
      Pages 61-77

    6. The Self-Destruction of Neurons Physiological and Pathophysiological Decisions for the Functional Integrity

      • J. H. M. Prehn, D. Kögel
      Pages 79-93

    7. The Organelles, I: Mitochondrial Failure And Neurodegeneration

      • A. D. Ortega, J. M. Cuezva
      Pages 95-110

    8. The Organelles II: Endoplasmic Reticulum and its Overload

      • W. Paschen
      Pages 111-121

    9. Transcriptional Dysfunctions as Pathogenic Mechanism of Neurodegenerative Diseases

      • B. Kaminska
      Pages 123-133

    10. Formation of Radicals

      • M. E. Götz, M. Gerlach
      Pages 135-164

  3. Axon guidance and repulsion. The molecular code of social life in the brain

    1. Axon Guidance and Repulsion. The Molecular Code of Social Life in the Brain

      • J. A. Del Río, F. de Castro, E. Soriano
      Pages 165-179

    2. Microglia and the Cerebral Defence System

      • D. van Rossum, U. K. Hanisch
      Pages 181-202

    3. Generation and Differentiation of Astrocytes During Central Nervous System Development And Injury

      • C. Vicario-Abejón, M. J. Yusta-Boyo
      Pages 203-213

    4. Oligodendrocytes in Health and Disease

      • M. Domercq, C. Matute
      Pages 215-230

    5. The Myelin Glial Cell of the Peripheral Nervous System: The Schwann Cell

      • D. Echevarría, S. Martínez
      Pages 231-243

    6. The Müller Glia: Role in Neuroprotection

      • E. Vecino, M. García
      Pages 245-257

  4. The Brave Neuron — Self Protection, Plasticity and Restoration

    1. Neural Plasticity and Regeneration: Myths and Expectations

      • J. M. Delgado-García, A. Gruart
      Pages 259-273

    2. Neuronal Protection Against Oxidative Damage

      • O. S. Jørgensen, A. S. Nielsen
      Pages 275-284

    3. Functional Recovery in the Peripheral and Central Nervous System After Injury

      • D. González-Forero, B. Benítez-Temino, R. R. de la Cruz, A. M. Pastor
      Pages 285-305
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About this book

Brain Damage and Repair aims to attract the interest of neuroscientists and clinical neurologists by building a novel bridge from molecular research to clinical therapy. This novel approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration. Comprehensive chapters on neurological diseases, such as M. Alzheimer, M. Parkinson, ALS, stroke or trauma, take this knowledge, apply it at the clinical level to provide a basis for novel therapeutic strategies. Brain Damage and Repair is completed with chapters on imaging techniques, viral gene transfer or legal international handling of stem cell transfer and patents of DNA/proteins.

Editors and Affiliations

  • Institute of Pharmacology, University of Kiel, Kiel, Germany

    T. Herdegen

  • Department of Neurosciences, University Pablo de Olavide, Sevilla, Spain

    J. Delgado-García

Bibliographic Information

  • Book Title: Brain Damage and Repair

  • Book Subtitle: From Molecular Research to Clinical Therapy

  • Editors: T. Herdegen, J. Delgado-García

  • DOI: https://doi.org/10.1007/1-4020-2541-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media B.V. 2004

  • Hardcover ISBN: 978-1-4020-1892-3Published: 29 February 2004

  • Softcover ISBN: 978-90-481-6538-4Published: 01 December 2010

  • eBook ISBN: 978-1-4020-2541-9Published: 08 May 2007

  • Edition Number: 1

  • Number of Pages: XIV, 721

  • Topics: Neurology, Neurosciences

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