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Optimization of Aerosol Drug Delivery

  • Conference proceedings
  • © 2003

Overview

Editors:
  1. Leon GradoĊ„

    1. University of Technology, Warsaw, Poland

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  2. Jan Marijnissen

    1. Faculty of Appplied Sciences, Delft University of Technology, Delft, The Netherlands

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  • Discusses the latest developments

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Table of contents (17 papers)

  1. Front Matter

    Pages I-IX
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  2. A History of the Development of Therapy by Jet Nebulisation

    • Ola Nerbrink
    Pages 1-22

  3. Molecular Modeling in Drug Design

    • Bogdan Lesyng, Witold Rudnicki
    Pages 23-48

  4. Particle Elaboration Using Supercritical Media for Drug Delivery Into the Human Lungs

    • Jerzy BaĊ‚dyga, Marek Henczka
    Pages 49-73

  5. Electrospray as Means to Produce Monodisperse Drug Particles

    • Kees B. Geerse, Jan C. M. Marijnissen
    Pages 75-90

  6. Optimization of Dry Powder Aerosols for Systemic Drug Delivery

    • Rita Vanbever
    Pages 91-103

  7. Recent Advances in Drug Delivery Via Pressured Metered-Dose Inhalers

    • John N. Pritchard
    Pages 105-121

  8. Resuspension of Powders and Deposition of Aerosol Particles in the Upper Human Airways

    • Leon GradoĊ„, Tomasz R. Sosnowski, Arkadiusz Moskal
    Pages 123-137

  9. Transport and Deposition of Hydrophilic Drug Particles in the Lungs — Experiment and Theory —

    • Joachim Heyder, Josef Gebhart, Christa Roth, George A. Ferron
    Pages 139-147

  10. Ventilation Modelling and Drug Deposition in Very Young Asthmatic Children

    • Frans de Jongh, Rupino Griffioen
    Pages 149-164

  11. Modeling Aerosol Drug Delivery

    • Yung Sung Cheng
    Pages 165-188

  12. Application of Electro Hydro Dynamic Atomisation in the Production of Engineered Drug Particles

    • Tomasz Ciach, Lidia Diaz, Esther van den IJssel, Jan C. M. Marijnissen
    Pages 189-204

  13. Interaction of Deposited Aerosol Particles with the Alveolar Liquid Layer

    • Tomasz R. Sosnowski, Leon GradoĊ„, Ferry Iskandar, Kikuo Okuyama
    Pages 205-216

  14. Pulmonary Deposition and Effects of Aerosolized Drugs in Pulmonary Patients

    • Eric Derom
    Pages 217-242

  15. Targetting Aerosols to Disease Areas

    • P. Zanen
    Pages 243-276

  16. Treatment of Asthma Patients Under Severe Conditions

    • Giuseppe A. Marraro
    Pages 277-293

  17. Understanding the Mechanisms of Local Pulmonary Drug Absorption and Metabolism: An in Vitro Model of the Airway Epithelium

    • Gerrit Borchard
    Pages 295-307

  18. Overview

    • Leon GradoĊ„, Jan Marijnissen
    Pages 309-311

  19. Back Matter

    Pages 313-315
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Keywords

About this book

Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy.
The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined.
The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.

Editors and Affiliations

  • University of Technology, Warsaw, Poland

    Leon GradoĊ„

  • Faculty of Appplied Sciences, Delft University of Technology, Delft, The Netherlands

    Jan Marijnissen

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