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From Molecules to Medicines

Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism

  • Conference proceedings
  • © 2009

Overview

Editors:
  1. Joel L. Sussman

    1. Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel

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    You can also search for this editor in PubMed   Google Scholar

  2. Paola Spadon

    1. Department of Chemical Sciences, University of Padova, Italy

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    You can also search for this editor in PubMed   Google Scholar

  • All chapters written by leading scientists in the field
  • Presents a state-of-the-art overview of the subject
  • First comprehensive book on the rapidly evolving field

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Table of contents (15 papers)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Surface Proteins of Gram-Positive Pathogens: Using Crystallography to Uncover Novel Features in Drug and Vaccine Candidates

    • Edward N. Baker, Thomas Proft, Haejoo Kang
    Pages 1-9

  3. The Rapid Crystallization Strategy for Structure-Based Inhibitor Design

    • Terese Bergfors
    Pages 11-19

  4. Fragment-Based Drug Discovery in Academia: Experiences From a Tuberculosis Programme

    • Timo J. Heikkila, Sachin Surade, Hernani L. Silvestre, Marcio V. B. Dias, Alessio Ciulli, Karen Bromfield et al.
    Pages 21-36

  5. Structural Biology Contributions to the Discovery of Drugs to Treat Chronic Myelogenous Leukemia

    • Sandra W. Cowan-Jacob, Gabriele Fendrich, Andreas Floersheimer, Pascal Furet, Janis Liebetanz, Gabriele Rummel et al.
    Pages 37-61

  6. Integrating Crystallography into Early Metabolism Studies

    • Gabriele Cruciani, Yasmin Aristei, Laura Goracci, Emanuele Carosati
    Pages 63-77

  7. The Foundations of Protein–Ligand Interaction

    • Gerhard Klebe
    Pages 79-101

  8. Structure-Based Design of Trna-Guanine Transglycosylase Inhibitors

    • Gerhard Klebe
    Pages 103-120

  9. Progress on New Hepatitis C Virus Targets: NS2 and NS5A

    • Joseph Marcotrigiano
    Pages 121-138

  10. Protein Structure Modeling

    • Narayanan Eswar, Andrej Sali
    Pages 139-151

  11. Structural Biology and Molecular Modeling in the Design of Novel DPP-4 Inhibitors

    • Giovanna Scapin
    Pages 153-168

  12. Tools to Make 3D Structural Data More Comprehensible: Emovie & Proteopedia

    • Eran Hodis, Jaime Prilusky, Joel L. Sussman
    Pages 169-182

  13. Structural Studies on Acetylcholinesterase and Paraoxonase Directed Towards Development of Therapeutic Biomolecules for the Treatment of Degenerative Diseases and Protection Against Chemical Threat Agents

    • Joel L. Sussman, Israel Silman
    Pages 183-199

  14. Protein Function Prediction from Structure in Structural Genomics and its Contribution to the Study of Health and Disease

    • James D. Watson, Janet M. Thornton
    Pages 201-215

  15. Crystal Structures of the β2-Adrenergic Receptor

    • William I. Weis, Daniel M. Rosenbaum, Søren G. F. Rasmussen, Hee-Jung Choi, Foon Sun Thian, Tong Sun Kobilka et al.
    Pages 217-230

  16. Can Structures Lead to Better Drugs? Lessons from Ribosome Research

    • Ada Yonath
    Pages 231-251
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Keywords

Editors and Affiliations

  • Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel

    Joel L. Sussman

  • Department of Chemical Sciences, University of Padova, Italy

    Paola Spadon

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