Sepsis and Organ Dysfunction

1. Front Matter

   Pages I-IX

   PDF

2. Introduction

   1. Introduction

      • A. E. Baue

      Pages 11-15

3. Sepsis and Organ Dysfunction. The Challenge Continues

   1. Sepsis and Organ Dysfunction. The Challenge Continues

      • G. Berlot, U. Lucangelo, A. Gullo

      Pages 17-33

4. Oxygen Transport in Sepsis

   1. Front Matter

      Pages 35-35

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   2. Biochemical Regulation of the Microcirculation

      • G. P. Novelli

      Pages 37-41

   3. Oxygen Supply and Consumption in Tissues

      • A. Mayr, W. Pajk, W. Hasibeder

      Pages 43-48

   4. Ischaemia-Reperfusion in Sepsis

      • C. Adembri, A. R. De Gaudio, G. P. Novelli

      Pages 49-56

   5. Mechanism of Oxygen Extraction Defect in Septic Shock

      • W. Pajk, H. Knotzer, W. Hasibeder

      Pages 57-63

5. Organ Dysfunction and Biohumoral Mismatch in Sepsis

   1. Front Matter

      Pages 65-65

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   2. Gut Perfusion in Sepsis and Shock

      • J. F. Pálizas

      Pages 67-76

   3. Pathophysiology of Encephalopathy

      • N. Latronico, G. F. Bussi, A. Candiani

      Pages 77-83

   4. Lung Dysfunction in the Early Phase of Sepsis

      • P. Neumann

      Pages 85-90

   5. The Kidney in Sepsis

      • J. A. Kellum

      Pages 91-101

   6. Pathophysiology of Liver Dysfunction in Sepsis

      • N. Brienza

      Pages 103-106

   7. Inflammatory Cells in Septic Shock

      • H. Zhang, C. Hsia, G. Porro

      Pages 107-112

6. Sepsis Trial

   1. Front Matter

      Pages 113-113

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   2. Revised Terminology on Sepsis

      • J.-L. Vincent

      Pages 115-121

   3. The Epidemiology and Outcome of Patients with Sepsis: Clear as Mud

      • R. S. Wax, D. C. Angus

      Pages 123-135

   4. Are There Useful New Markers of Sepsis?

      • M. Meisner, K. Reinhart

      Pages 137-143

   5. A Paradigm Shift: The Bidirectional Effect of Inflammation on Bacterial Growth

      • G. U. Meduri

      Pages 145-154

An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.

• Sepsis
• epidemiology
• pathophysiology
• respiration
• shock

• Department of Surgery, Health Sciences Center, Saint Louis University, St. Louis, USA

  A. E. Baue

• Department of Anaesthesia, Intensive Care and Pain Therapy, Cattinara Hospital, University of Trieste, Trieste, Italy

  G. Berlot, A. Gullo

• Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium

  J.-L. Vincent

Policies and ethics