The Genetics of Complex Thyroid Diseases

1. Front Matter

   Pages II-XI

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2. Autoimmune Thyroid Diseases

   1. Front Matter

      Pages 1-1

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   2. Genetic Dissection of Familial Autoimmune Thyroid Diseases Using Whole Genome Screening

      • Yaron Tomer

      Pages 3-22

   3. Genome Screening for Graves’ Disease Susceptibility Loci in U.K. Families

      • B. Vaidya, H. Imrie, P. Kendall-Taylor, S. H. S. Pearce

      Pages 23-41

   4. The Involvement of the HLA Region in Genetic susceptibility to Graves’ disease

      • J. M. Heward

      Pages 42-54

   5. HLA and Autoimmune Thyroid Diseases

      • Ken Yamamoto, Takehiko Sasazuki

      Pages 55-63

   6. What Can We Learn from the Genetics of Diabetes?

      • Donald W. Bowden

      Pages 64-80

   7. The Genomic Biology of the Human Chromosome 2q33 Costimulatory Receptor Region

      • Vincent Ling, Gregory J. Fisk

      Pages 81-102

   8. CTLA-4 Gene in the Pathogenesis of Graves’ Disease

      • Tatsuo Yanagawa, Tsuyoshi Kouki, Leslie J. DeGroot

      Pages 103-107

   9. The evolving role of CTLA-4 in the genetic predisposition to AITD

      • Giuseppe Barbesino

      Pages 108-122

   10. Association of AITD with Microsatellite Markers for TSHR and CTLA-4 in Japanese Patients

       • Takashi Akamizu

       Pages 123-136

3. Familial Thyroid Cancers

   1. Front Matter

      Pages 137-137

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   2. Familial Non Medullary Thyroid Cancer

      • Orlo H. Clark

      Pages 139-150

   3. Cowden Disease and the PTEN/MMAC1 Gene

      • Bryan McIver, Norman L. Eberhardt

      Pages 151-175

   4. Molecular Mechanisms of RET Activation in Human Neoplasia

      • Massimo Santoro, Francesca Carlomagno, Rosa Marina Melillo, Giancarlo Vecchio, Alfredo Fusco

      Pages 176-183

   5. Lessons From Chernobyl; Need for Molecular Epidemiology of Childhood Thyroid Cancer

      • Shunichi Yamashita, Hiroyuki Namba, Noboru Takamura, Kiyoto Ashizawa, Yoshisada Shibata

      Pages 184-197

   6. Genetic Events in Radiation-Induced Thyroid Cancer

      • Yuri E. Nikiforov

      Pages 198-219

4. Back Matter

   Pages 220-222

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The rapid developments in molecular genetics have clarified many of the muta­ tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method­ ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis­ ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup­ ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con­ cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin­ guished researchers from the United States, the United Kingdom, France, Ger­ many, Italy, and Japan were invited. Each presentation precipitated intense dis­ cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.

• Chromosom
• Diabetes
• Graves's disease
• Hashimoto's thyroiditis
• Termination
• autoimmune thyroid disease
• familial thyroid-cancer
• genes
• genetics
• molecular mechanisms

• Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

  Takashi Akamizu

• Department of Internal Medicine, Kobe University School of Medicine, Chuo-ku, Kobe, Japan

  Masato Kasuga

• Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA

  Terry F. Davies

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