Ischemic Blood Flow in the Brain

1. Front Matter

   Pages I-XX

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2. Honorary Lecture

   1. Front Matter

      Pages 1-1

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   2. Historical Review of Developments in the Field of Cerebral Blood Flow and Metabolism

      • Louis Sokoloff

      Pages 3-10

3. Endothelium, Mechanosensors, Glycocalyx

   1. Front Matter

      Pages 11-11

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   2. Mechanisms of Mechanochemical Transduction in Vascular Cells

      • Shu Chien, John Y. J. Shyy

      Pages 13-19

   3. Ultra Long Range Forces Between Macroscopic Bodies

      • Hiroyuki Ohshima

      Pages 20-24

   4. Role of the Endothelial Surface Coat in Microvessel Blood Flow

      • Peter Gaehtgens, Axel R. Pries

      Pages 25-32

   5. Blood-Brain Barrier: Role of Brain Endothelial Surface Charge and Glycocalyx

      • Barbro B. Johansson

      Pages 33-38

   6. The Role of the Endothelial Surface Coat in Microvascular Permeability

      • C. Charles Michel

      Pages 39-46

4. Endothelium, BBB Disruption

   1. Front Matter

      Pages 47-47

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   2. Mechanism of Inhibitory Effect of Hypoxia/Reoxygenation on Gap Junctional Intercellular Communication of Vascular Endothelial Cells in Culture

      • Masamichi Nishida, Ikuo Morita, Sei-Itsu Murota

      Pages 49-56

   3. Proteolytic Opening of the Blood-Brain Barrier During Neuroinflammation

      • Gary A. Rosenberg, Diedre Hofinger, Edward Y. Estrada, James A. Wallace

      Pages 57-63

   4. Endothelial Dysfunction After Brain Ischemia and Reperfusion

      • Timur D. Vlasov, Victor I. Amosov, Dmitry E. Korzhevski

      Pages 64-69

   5. Local Blood-Brain Barrier Damage,Cerebral Edema,and Cell Injury During Reperfusion After 2 Hours of Focal Cerebral Ischemia

      • Joseph Fenstermacher, Ling Wei, Kai-Feng Liu, Tavarekere Nagaraja

      Pages 70-75

   6. Temporal Profile of Ischemic Edema:Comparison of Ultrastructure,Gravimetry, and Evans Blue Permeability

      • U. Ito, T. Kuroiwa, S. Hanyu, Y. Hakamata, S. Ito, I. Nakano et al.

      Pages 76-82

   7. Perivascular Cells of Small Cerebral Vessels (FGP, Mato cells) and Their Permeability Under Pathological Conditions

      • Masao Mato

      Pages 83-88

5. Ischemia and Gene Expression

   1. Front Matter

      Pages 89-89

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   2. Effects of lschemia on Expression of Cyclooxygenase and Endothelial Nitric Oxide Synthase in the Cerebral Circulation

      • David W. Busija, Ferenc Domoki, Nishadi Thrikawala, Ferenc Bari

      Pages 91-97

   3. Role of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in the Mechanisms of Ischemic Brain Injury

      • Costantino Iadecola, Shigeru Nogawa, Masao Nagayama, Tomiko Nagayama, Kiyoshi Niwa, Xueren Zhao et al.

      Pages 98-107

   4. Dual Pathways of Free Radical Injury in Vascular Endothelial Cells: Loss of Nuclear DNA Integrity and Membrane Asymmetry During Enhanced Cysteine Protease Activity

      • Kenneth Maiese, Shi-Hua Lin, Andrea M. Vincent

      Pages 108-119

Because stroke is essentially a disease of the vessels and blood flow, the most fundamental aspects of ischemic blood flow in the brain are under investigation by researchers. Their work was the focus of the sixth in the series of Keio University International Symposia for Life Sciences and Medicine, held in Tokyo in 1999. Selected here are 55 papers from the symposium, covering the buffy coat (glycocalyx) of endothelial cells, the blood-brain barrier and permeability, gene expression, vascular reactivity, dysregulation, inflammatory deterioration, cortical spreading depression, edema, microvascular derangement, and pathology, in ten major sections. The book includes the thought-provoking discussions that followed the presentations, thus providing an invaluable source of up-to-date information not only for researchers investigating microcirculation but also for clinicians implementing the most effective treatment for stroke patients.

• Glycocalyx
• Inflammatory process in ischemia
• Ischemic derangement of cerebral blood flow
• brain
• circulation
• depression
• disturbed vascular reactivity
• oxidative stress
• spreading depression
• stroke

• Department of Neurology School of Medicine, Keio University, Tokyo, Japan

  Yasuo Fukuuchi, Minoru Tomita, Atsuo Koto

Policies and ethics