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Table of contents (17 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.
Editors and Affiliations
Bibliographic Information
Book Title: Molecular Pathology of Gastroenterological Cancer
Book Subtitle: Application to Clinical Practice
Editors: Eiichi Tahara
DOI: https://doi.org/10.1007/978-4-431-65915-0
Publisher: Springer Tokyo
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eBook Packages: Springer Book Archive
Copyright Information: Springer Japan 1997
Hardcover ISBN: 978-4-431-70195-8Due: 01 October 1997
Softcover ISBN: 978-4-431-65917-4Published: 03 October 2013
eBook ISBN: 978-4-431-65915-0Published: 29 June 2013
Edition Number: 1
Number of Pages: VIII, 267
Number of Illustrations: 60 b/w illustrations, 8 illustrations in colour