IgG4-Related Kidney Disease

1. Front Matter

   Pages i-xi

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2. General Remarks

   1. Front Matter

      Pages 1-1

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   2. IgG4-Related Disease: History and Overview

      • Shigeyuki Kawa

      Pages 3-24

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   3. IgG4-Related Disease: Pathological Features and Differential Diagnosis

      • Yoh Zen

      Pages 25-41

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   4. Potential Pathways in the Pathogenesis of IgG4-Related Disease

      • Masafumi Moriyama, Seiji Nakamura

      Pages 43-54

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   5. Does IgG4-Related Disease Have an Autoimmune Basis?

      • Takako Saeki, Mitsuhiro Kawano

      Pages 55-63

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   6. Plasmablasts: A Promising Biomarker in IgG4-Related Disease

      • Marco Lanzillotta, John H. Stone, Emanuel Della-Torre

      Pages 65-72

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3. Features of IgG4-Related Kidney Disease and Associated Conditions

   1. Front Matter

      Pages 73-73

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   2. Overview of IgG4-Related Kidney Disease

      • Takao Saito

      Pages 75-83

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   3. IgG4-Related Kidney Disease: Clinical and Laboratory Features

      • Shinichi Nishi, Takako Saeki

      Pages 85-96

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   4. Imaging Findings

      • Dai Inoue, Yoh Zen, Mitsuhiro Kawano, Osamu Matsui, Toshifumi Gabata

      Pages 97-104

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   5. Characteristic Tubulointerstitial Nephritis in IgG4-Related Kidney Disease

      • Michio Nagata, Satoshi Hara

      Pages 105-113

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   6. Electron Microscopic Findings

      • Nobuaki Yamanaka

      Pages 115-123

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   7. IgG4-Related Kidney Disease: Pathological Features: Membranous Glomerulonephritis

      • Mariam Priya Alexander, Lynn D. Cornell

      Pages 125-137

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   8. IgG4-Related Kidney Disease: Pathological Features: Other Glomerular Disease

      • Satoshi Hisano

      Pages 139-143

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   9. IgG4-Related Kidney Diseases and Conditions: Renal Pelvic and Ureteral Diseases

      • Kenichi Harada, Yoshifumi Ubara

      Pages 145-157

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   10. Retroperitoneal Fibrosis/Periaortitis and Hydronephrosis

       • Ichiro Mizushima, Dai Inoue, Mitsuhiro Kawano

       Pages 159-171

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   11. Other Urogenital Lesions (Testis, Paratesticular Lesion, Bladder, Prostate etc.)

       • Takeshi Uehara, Yasunari Fujinaga, Teruyuki Ogawa, Shigeyuki Kawa

       Pages 173-185

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   12. Characteristic Distribution of Inflammatory Lesions in IgG4-Related Kidney Disease: Findings from Autopsy Case Series

       • Satoshi Hara, Mitsuhiro Kawano, Ichiro Mizushima, Kenichi Harada, Takuma Takata, Takako Saeki et al.

       Pages 187-191

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   13. Diagnosis of IgG4-Related Kidney Disease

       • Mitsuhiro Kawano, Kazunori Yamada

       Pages 193-201

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This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

• IgG4
• IgG4-related disease
• IgG4RKD
• Membranous glomerulonephritis
• Tubulointerstitial nephritis

• Faculty of Medicine, Fukuoka University, Japan

  Takao Saito

• Rheumatology Clinic / Yawkey 2, Massachusetts General Hospital, Boston, USA

  John H. Stone

• Department of Internal Medicine, Faculty of Medicine Fukuoka University, Japan

  Hitoshi Nakashima

• Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan

  Takako Saeki

• Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan

  Mitsuhiro Kawano

Takao Saito, Emeritus Professor, Faculty of Medicine, Fukuoka UniversityJohn H. Stone, Massachusetts General Hospital 
Hitoshi Nakashima, Division of Nephrology & Rheumatology, Department of Internal Medicine, Fukuoka University 
Takako Saeki, Department of Internal Medicine, Nagaoka Red Cross Hospital 
Mitsuhiro Kawano, Division of Rheumatology, Department of Internal Medicine, Kanazawa University

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