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PEGylated Protein Drugs: Basic Science and Clinical Applications

  • Book
  • © 2009

Overview

Editors:
  1. Francesco M. Veronese

    1. Department of Pharmaceutical Sciences, University of Padova, Padova, Italy

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  • Vast information on PEG and PEG-conjugates collected in one book
  • Competent authorship from academia and industry assures comprehensive information
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-IX
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  2. Preface PEGylated protein conjugates: A new class of therapeutics for the 21st century

    • Ruth Duncan, Francesco M. Veronese
    Pages 1-9

  3. Protein PEGylation, basic science and biological applications

    • Francesco M. Veronese, Anna Mero, Gianfranco Pasut
    Pages 11-31

  4. Reactive PEGs for protein conjugation

    • Gian Maria Bonora, Sara Drioli
    Pages 33-45

  5. Rebridging disulphides: site-specific PEGylation by sequential bis-alkylation

    • Ji-Won Choi, Antony Godwin, Sibu Balan, Penny Bryant, Yuehua Cong, Estera Pawlisz et al.
    Pages 47-73

  6. Enzymatic techniques for PEGylation of biopharmaceuticals

    • Mauro Sergi, Francesca Caboi, Carlo Maullu, Gaetano Orsini, Giancarlo Tonon
    Pages 75-88

  7. The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites

    • Angelo Fontana, Barbara Spolaore, Anna Mero, Francesco M. Veronese
    Pages 89-112

  8. Protein conjugates purification and characterization

    • Conan J. Fee
    Pages 113-125

  9. PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals

    • Rob Webster, Victoria Elliott, B. Kevin Park, Donald Walker, Mark Hankin, Philip Taupin
    Pages 127-146

  10. The occurrence, induction, specificity and potential effect of antibodies against poly(ethylene glycol)

    • Jonathan K. Armstrong
    Pages 147-168

  11. Pegfilgrastim — designing an improved form of rmetHuG-CSF

    • Graham Molineux
    Pages 169-185

  12. PEGylation of human growth hormone: strategies and properties

    • Rory F. Finn
    Pages 187-203

  13. PEGylated α interferons: two different strategies to achieve increased efficacy

    • Gianfranco Pasut
    Pages 205-216

  14. Development of PEGylated mammalian urate oxidase as a therapy for patients with refractory gout

    • Michael S. Hershfield, John S. Sundy, Nancy J. Ganson, Susan J. Kelly
    Pages 217-227

  15. Certolizumab pegol: a PEGylated anti-tumour necrosis factor alpha biological agent

    • Andrew M. Nesbitt, Sue Stephens, Elliot K. Chartash
    Pages 229-254

  16. PEG: a useful technology in anticancer therapy

    • Anna Mero, Gianfranco Pasut, Francesco M. Veronese
    Pages 255-271

  17. Regulatory strategy and approval processes considered for PEG-drug conjugates and other nanomedicines

    • Tacey X. Viegas, Francesco M. Veronese
    Pages 273-281

  18. Back Matter

    Pages 283-287
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Keywords

About this book

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Reviews

From the reviews:

“The volume is dedicated to the recent advances on PEGylation and PEGylated compunds. It represents an excellent update in the evolution of this field, from nanoscience to clinical applications. The book provides an excellent update in this rapidly evolving field. … This valuable volume which will spark the interest of both researchers and clinicians contributes to a better understanding of polymer therapeutics.” (Magdalena Moisei, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

Editors and Affiliations

  • Department of Pharmaceutical Sciences, University of Padova, Padova, Italy

    Francesco M. Veronese

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