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Birkhäuser

Lymphocyte Trafficking in Health and Disease

  • Book
  • © 2006

Overview

Editors:
  1. Raffaele Badolato

    1. Department of Pediatrics, University of Brescia, Brescia, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Silvano Sozzani

    1. Section of General Pathology and Immunology, University of Brescia, Brescia, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Special focus on diseases and targets of therapeutical intervention
  • International authorship
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
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  2. Lymphocyte trafficking: from immunology paradigms to disease mechanisms

    1. Lymphocyte trafficking: from immunology paradigms to disease mechanisms

      • Raffaele Badolato, Silvano Sozzani
      Pages 1-3

  3. Physiology of lymphocyte trafficking

    1. Front Matter

      Pages 5-5
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    2. Biology of chemokines

      • Gao Ping, Ji Ming Wang, O. M. Zack Howard, Joost J. Oppenheim
      Pages 7-38

    3. Lymphocyte-endothelial cell interaction

      • Gabriela Constantin, Carlo Laudanna
      Pages 39-54

    4. Chemokine receptor expression in effector and memory T cell subsets

      • Mara Messi, Federica Sallusto
      Pages 55-70

    5. Migration of dendritic cell subsets

      • Silvano Sozzani, Annalisa Del Prete, Karel Otero, Amerigo Santoro, William Vermi, Fabio Facchetti
      Pages 71-93

    6. Migration of NK cells

      • Angela Gismondi, Angela Santoni
      Pages 95-112

  4. Immunopathology of lymphocyte trafficking

    1. Front Matter

      Pages 113-113
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    2. Lymphocyte trafficking and chemokine receptors during pulmonary disease

      • Nicholas W. Lukacs, Matthew Schaller
      Pages 115-131

    3. Lymphocyte migration to the brain

      • Ineke M. Dijkstra, Richard M. Ransohoff
      Pages 133-149

    4. Lymphocyte migration to the kidney

      • Takashi Wada, Hitoshi Yokoyama, Shuichi Kaneko, Kouji Matsushima
      Pages 151-165

    5. Leukocyte migration to pancreatic islets: a critical step in the pathogenesis of type 1 diabetes

      • Nadia Giarratana, Giuseppe Penna, Susana Amuchastegui, Roberto Mariani, Luciano Adorini
      Pages 167-179

    6. Controlling leukocyte trafficking in disease

      • Christopher A. Haskell, Richard Horuk
      Pages 181-196

  5. Inherited disorders of lymphocyte trafficking

    1. Front Matter

      Pages 197-197
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    2. Leukocyte adhesion deficiency

      • Amos Etzioni
      Pages 199-210

    3. Wiskott-Aldrich syndrome as a model of cytoskeleton defects

      • Gerben Bouma, Adrian J. Thrasher, Siobhan Burns
      Pages 211-231

    4. From CXCR4 mutations to WHIM syndrome

      • Raffaele Badolato, Vanessa Bonomi, Laura Tassone
      Pages 233-242

  6. Back Matter

    Pages 243-249
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Keywords

About this book

Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.

Editors and Affiliations

  • Department of Pediatrics, University of Brescia, Brescia, Italy

    Raffaele Badolato

  • Section of General Pathology and Immunology, University of Brescia, Brescia, Italy

    Silvano Sozzani

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