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Birkhäuser

Toll-like Receptors in Inflammation

  • Book
  • © 2005

Overview

Editors:
  1. Luke A.J. O’Neill

    1. Cytokine Research Group, Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland

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    You can also search for this editor in PubMed   Google Scholar

  2. Elizabeth Brint

    1. Cytokine Research Group, Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Written by leading scientists in the field
  • Covers the current understanding of TLRs and their role in inflammatory diseases
  • Gives outlook on the development of drugs
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. TLRs as bacterial sensors

    • Kasper Hoebe, Bruce Beutler
    Pages 1-17

  3. Toll-like receptors and rheumatoid arthritis: is there a connection?

    • Sandra M. Sacre, Stefan K. Drexler, Brian M. Foxwell
    Pages 19-40

  4. Toll-like receptor 9 and systemic autoimmune diseases

    • Simon Rothenfusser, Eicke Latz
    Pages 41-61

  5. Toll-like receptors and airway disease

    • John W. Hollingsworth, Donald N. Cook, David A. Schwartz
    Pages 63-86

  6. Toll-like receptors and vascular disease

    • Kathrin S. Michelsen, Terence M. Doherty, Moshe Arditi
    Pages 87-106

  7. Toll-like receptors and inflammatory bowel disease

    • Masayuki Fukata, Maria T. Abreu
    Pages 107-123

  8. Toll-like receptor signaling in the liver

    • Ekihiro Seki, David A. Brenner, Robert F. Schwabe
    Pages 125-142

  9. Toll-like receptors as key sensors of viral infection

    • Sinéad E. Keating, Andrew G. Bowie
    Pages 143-171

  10. IRAK-4: A key kinase involved in toll-like receptor signaling and resistance to bacterial infection

    • Andrei E. Medvedev, Douglas B. Kuhns, John I. Gallin, Stefanie N. Vogel
    Pages 173-192

  11. Endogenous regulation of toll-like receptor signalling

    • Elizabeth Brint
    Pages 193-211

  12. Tuning of inflammatory cytokines and toll-like receptors by TIR8/SIGIRR, a member of the IL-1 receptor family with unique structure and regulation

    • Cecilia Garlanda, Michela Mosca, Alessia Cotena, Virginia Maina, Federica Moalli, Federica Riva et al.
    Pages 213-222

  13. Toll-like receptors as pharmacological targets

    • Bruno Conti, Christopher N. Davis, M. Margarita Behrens, Julius Rebek, Tamas Bartfai
    Pages 223-240

  14. Back Matter

    Pages 241-246
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Keywords

About this book

A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.

Editors and Affiliations

  • Cytokine Research Group, Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland

    Luke A.J. O’Neill, Elizabeth Brint

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