Clinical Pharmacology of Sleep

1. Front Matter

   Pages I-XVIII

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2. Primary and secondary insomnia

   • Kenneth L. Lichstein, Les A. Gellis, Kristin C. Stone, Sidney D. Nau

   Pages 1-9

3. Primary insomnia: diagnosis and treatment

   • Pavlos Sakkas, Constantin R. Soldatos

   Pages 11-19

4. Neuropharmacology of obstructive sleep apnea and central apnea

   • Peter R. Buchanan, Ronald R. Grunstein

   Pages 21-41

5. Narcolepsy syndrome: a new view at the beginning of the second millennium

   • Christian Guilleminault, Yu-Shu Huang, Chia-Mo Lin

   Pages 43-59

6. Sleep disturbances in restless legs syndrome (RLS) and periodic limb movements (PLM)

   • Marco Zucconi, Mauro Manconi

   Pages 61-79

7. Sleep disturbances in anxiety disorders

   • Chien-Ming Yang, Hsiao-Sui Lo, Arthur J. Spielman

   Pages 81-100

8. Sleep disturbances in affective disorders

   • Luc Staner, Remy Luthringer, Olivier Le Bon

   Pages 101-124

9. Sleep disturbance in schizophrenia

   • Roger Godbout

   Pages 125-131

10. Clinical pharmacology of sleep disturbances in children and adolescents

    • Judith A. Owens, Manisha B. Witmans

    Pages 133-152

11. Assessment and treatment of sleep disturbances in aged population

    • Tejas R. Shah, Nikola N. Trajanovic, Colin M. Shapiro

    Pages 153-172

12. Sleep disturbances in Alzheimer’s disease

    • Michael V. Vitiello

    Pages 173-182

13. Sleep disturbance during menopause

    • Päivi Polo-Kantola

    Pages 183-196

14. Chronopharmacology and its implications to the pharmacology of sleep

    • Daniel P. Cardinali, Seithikurippu R. Pandi-Perumal

    Pages 197-206

15. Overview of currently available benzodiazepine and nonbenzodiazepine hypnotics

    • Jaime M. Monti, Daniel Monti

    Pages 207-223

16. Rebound and withdrawal with benzodiazepine and non-benzodiazepine hypnotic medication

    • Malcolm Lader

    Pages 225-234

17. Back Matter

    Pages 235-239

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From the emergence of clinical sleep medicine marked by the establishment of the harbinger Stanford Sleep Disorders Clinic in the mid 1970s, offspring sleep dis- ders clinics and centers have grown exponentially with the recognition of the unmet diagnostic and treatment needs of the reservoir of patients suffering from sy- toms of what are now recognized and classi?ed as the nosology of human sleep disorders. Important in the growing armamentarium of treatment options for the sleep practitioner are both traditional and newer pharmacological agents, including over-the-counter, non-traditional, and prescription types, that are all used to treat, sometimes adjunctively, most clinically recognized sleep disorders. Although there are numerous academic treatises and reviews dealing with in- vidual treatment alternatives for the diversity of recognized sleep disorders, no one comprehensive resource, extant, has dealt with pharmacological treatment options and strategies for the major human sleep disorders associated with a panoply of symptomatic conditions. The present volume and its series of chapters individually focusing on a range of human conditions, from pediatric sleep disorders to sle- relateddisordersofindividualssufferingfromAlzheimer’sdementia,uniquelycover the wide range of human medical conditions amenable to thoughtfully sleep-related applied drug therapy. The Editors have brought together a superb group of internationally respected sleep clinicians, and researchers, that provide state-of-the-art analysis of the current basic and clinical perspective regarding the most common sleep disorders that are amenable to pharmacological treatment. In each chapter the authors outline a th- oughhistoricalbackgroundoftheparticulardisorderandreviewthebasicpre-clinicalstudies leading to current treatment options.

• Alzheimer
• Sleep Disorders
• Syndrom
• alzheimer's disease
• assessment
• attention
• diagnosis
• medicine
• menopause
• neuropharmacology
• pharmacology
• schizophrenia
• syndromes

• Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, USA

  S. R. Pandi-Perumal

• Pharmacology and Therapeutics, Montevideo, Uruguay

  Jaime M. Monti

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