Bone Morphogenetic Proteins: Regeneration of Bone and Beyond

1. Front Matter

   Pages i-xi

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2. Bone morphogenetic proteins and their role in regenerative medicine

   • Kuber T. Sampath

   Pages 1-8

3. Bone morphogenetic protein receptors and their nuclear effectors in bone formation

   • Olexander Korchynskyi, Rutger L. van Bezooijen, Clemens W. G. M. Löwik, Peter ten Dijke

   Pages 9-44

4. Biology of bone morphogenetic proteins

   • Snjezana Martinovic, Petra Simic, Fran Borovecki, Slobodan Vukicevic

   Pages 45-72

5. Bone morphogenetic proteins in development

   • Petra Simic, Slobodan Vukicevic

   Pages 73-108

6. Bone morphogenetic proteins in articular cartilage repair

   • David C. Rueger, Susan Chubinskaya

   Pages 109-132

7. Craniofacial reconstruction with bone morphogenetic proteins

   • Hendrik Terheyden, Søren Jepsen

   Pages 133-155

8. Clinical experience of osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones

   • Gary E. Friedlaender

   Pages 157-162

9. Development of the first commercially available recombinant human bone morphogenetic protein (rhBMP-2) as an autograft replacement for spinal fusion and ongoing R&D direction

   • Bill McKay

   Pages 163-185

10. Bone morphogenetic proteins and the synovial joints

    • Frank P. Luyten, Rik Lories, Dirk De Valck, Cosimo De Bari, Francesco Dell’Accio

    Pages 187-212

11. The role of bone morphogenetic proteins in developing and adult kidney

    • Fran Borovecki, Petra Simic, Lovorka Grgurevic, Slobodan Vukicevic

    Pages 213-243

12. Bone morphogenetic proteins in the nervous system

    • Pamela Lein, Dennis Higgins

    Pages 245-266

13. Bone morphogenetic proteins and cancer

    • Joachim H. Clement, Stefan Wölfl

    Pages 267-292

14. Bone healing: Bone morphogenetic proteins and beyond

    • Vishwas M. Paralkar, William A. Grasser, Keith A. Riccardi, David D. Thompson, Slobodan Vukicevic

    Pages 293-305

15. Back Matter

    Pages 305-312

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Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica­ cy of BMPs in almost all crucial developmental events as well as during regenera­ tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti­ lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.

• biology
• bone
• cancer
• cartilage
• development
• diseases
• kidney
• nephrology
• oncology
• prostate cancer
• protein
• proteins
• regeneration
• regenerative medicine
• tissue

• Laboratory for Mineralized Tissues, School of Medicine, Zagreb, Croatia

  Slobodan Vukicevic

• Genzyme Corporation, Framingham, USA

  Kuber T. Sampath

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