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Regulatory T Cells in Inflammation

  • Book
  • © 2005

Overview

Editors:
  1. Leonie S. Taams

    1. Infection & Immunity Research Group, Franklin-Wilkins Building, King's College London, London, UK

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  2. Marca H. M. Wauben

    1. Department of Immunohematology and Blood Transfusion, E3-Q, Leiden University Medical Center, Leiden, The Netherlands

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  3. Arne N. Akbar

    1. Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London, UK

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  • Potential use of regulatory T cells as targets for immunotherapy (diabetes, multiple sclerosis, RA, IBD)
  • Focus on CD4+/CD25+ regulatory T-cells
  • International authorship
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xi
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  2. Origin, function and distribution of regulatory T cells

    1. History of CD25+CD4+ regulatory T cells

      • Shimon Sakaguchi, Noriko Sakaguchi
      Pages 3-17

    2. “Natural” and “induced” regulatory T cells — purpose and problems associated with an emerging distinction

      • Dirk Homann, Matthias G. von Herrath
      Pages 19-38

    3. The role of interleukin-10 in regulatory-T-cell suppression: reconciling the discrepancies

      • Robert N. Barker, Frank J. Ward
      Pages 39-61

    4. Activation and distribution of regulatory T cells in naïve and antigen-stimulated immune systems

      • Esther N.M. Nolte-’t Hoen, Marca H.M. Wauben
      Pages 63-75

    5. Regulatory T cells and the innate immune system

      • Kevin J. Maloy, Fiona Powrie
      Pages 77-91

  3. The potential use of regulatory T cells in immunotherapy

    1. Exploiting the potential of regulatory T cells in the control of type 1 diabetes

      • Nadia Giarratana, Giuseppe Penna, Silvia Gregori, Kenn C. Daniel, Luciano Adorini
      Pages 95-109

    2. Regulatory T cells in type 1 autoimmune diabetes

      • Sophie Candon, Lucienne Chatenoud
      Pages 111-132

    3. The potential for targeting CD4+CD25+ regulatory T cells in the treatment of multiple sclerosis in humans

      • Clare Baecher-Allan, Vissia Viglietta, David A. Hafler
      Pages 133-151

    4. Immunotherapy of rheumatoid arthritis using CD4+CD25+ regulatory T cells

      • Jocea M. van Amelsfort, Johannes W. J. Bijlsma, Leonie S. Taams
      Pages 153-172

    5. Potential for manipulation of regulatory T cells in treatment or prevention of allergic disease

      • Douglas S. Robinson, Eleanor M. Ling
      Pages 173-203

    6. The role of regulatory T cells in cutaneous disorders

      • Katie E. Birch, Milica Vukmanovic-Stejic, John R. Reed, Malcolm H.A. Rustin, Arne N. Akbarl
      Pages 205-219

    7. The potential role of CD25+CD4+ regulatory T cells in the induction and maintenance of transplantation tolerance in humans

      • Kathryn J. Wood, Ahmed Akl
      Pages 221-236

  4. Back Matter

    Pages 237-240
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Keywords

About this book

Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent.

Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.

Editors and Affiliations

  • Infection & Immunity Research Group, Franklin-Wilkins Building, King's College London, London, UK

    Leonie S. Taams

  • Department of Immunohematology and Blood Transfusion, E3-Q, Leiden University Medical Center, Leiden, The Netherlands

    Marca H. M. Wauben

  • Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London, UK

    Arne N. Akbar

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