Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

1. Front Matter

   Pages I-VIII

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2. Naturally Occurring β-Lactams

   • R. Southgate, S. Elson

   Pages 1-106

3. New Techniques for the Mass Spectrometry of Natural Products

   • I. Howe, M. Jarman

   Pages 107-152

4. Chemical Synthesis of the Trichothecenes

   • P. G. McDougal, N. R. Schmuff

   Pages 153-219

5. Quassinoid Bitter Principles II

   • Judith Polonsky

   Pages 221-264

6. Back Matter

   Pages 265-292

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More than ten years have elapsed since the publication of a compre­ hensive review on the quassinoids, the bitter principles of the Simaroubaceae family (80). Interest in these terpenoids has increased enormously in recent years due in part to the finding of the American National Cancer Institute in the early 1970s that these compounds display marked antileukemic activity. Furthermore, a wide spectrum of other biological properties for the quassinoids has been discovered and studies on chemical modifications of inactive members to yield biologically active ones were undertaken. New structures have been established also and numerous synthetic approaches have been developed which include the total synthesis of the parent compound, quassin (p. 250) and also that of castelanolide (p. 253). It is intended that this present chapter will be an extension of my first review in this series and will contain references up to September 1984. A short article on some aspects of this subject was published recently (81). II. Quassinoid General Features In reviewing the essential features of the quassinoids, the new structural types discovered during the last decade will be emphasised. The quassinoids can be divided into distinct groups according to their basic skeletons. The five skeletons observed are presented on Chart 1.

• chemistry
• natural product

• Department of Chemistry, The Florida State University, Tallahassee, USA

  W. Herz

• Biologisches Institut II, Lehrstuhl für Biochemie der Pflanzen, Albert-Ludwigs-Universität, Freiburg i. Br., Federal Republic of Germany

  H. Grisebach

• Chemistry Department, The University, Glasgow, Scotland

  G. W. Kirby

• Institut für Organische Chemie, Universität Basel, Basel, Switzerland

  Ch. Tamm

• Research Division, Beecham Pharmaceuticals, Betchworth, Surrey, UK

  S. Elson, R. Southgate

• Drug Metabolism Team, Section of Drug Development, Cancer Research Campaign Laboratory, Institute of Cancer Research, Sutton, Surrey, UK

  I. Howe, M. Jarman

• Department of Chemistry, Georgia Institute of Technology, Atlanta, USA

  P. G. McDougal

• Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France

  Judith Polonsky

• Questel, Inc., USA

  N. R. Schmuff

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