The Nucleolus and Ribosome Biogenesis

1. Front Matter

   Pages I-XI

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2. Introduction

   • Asen A. Hadjiolov

   Pages 1-4

3. Ribosomal Genes

   • Asen A. Hadjiolov

   Pages 5-53

4. Transcription of Ribosomal Genes

   • Asen A. Hadjiolov

   Pages 54-86

5. Maturation of Preribosomes

   • Asen A. Hadjiolov

   Pages 87-110

6. Molecular Architecture of the Nucleolus

   • Asen A. Hadjiolov

   Pages 111-132

7. Regulation

   • Asen A. Hadjiolov

   Pages 133-164

8. Ribosome Biogenesis in the Life Cycle of Normal and Cancer Cells

   • Asen A. Hadjiolov

   Pages 165-196

9. Back Matter

   Pages 197-271

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The nucleolus had consistently attracted the attention of investigators in the fields of cell biology and pathology. Because of its ubiquitous presence in the nucleus of eukaryotic cells, its rapid changes during their life cycle, and its rapid response to noxious agents, this organelle has been the subject of a large number of studies. Yet, the exact function and the very reason for the existence of the nucleolus (the only large cellular structure not delimited by a membrane) remain largely unknown. The ribosomes were discovered relatively late in the study of cells, but due to their crucial involvement in the protein synthesis machinery of all living organisms, the elucidation of their structure and function quickly became one of the major goals of molecular biology. The relatively simple structure of the ribosome strengthens the hope that a full understanding of the structure and function of this organelle in molecular terms is within the reach of contemporary research~ Since each of the rRNA and protein molecules embodied in the ribosome is the product of a distinct gene, studies on the biogenesis of ribosomes expanded rapidly to become a core topic in molecular genetics.

• DNA
• RNA
• biology
• cell biology
• enzymes
• membrane
• molecular biology
• molecular genetics
• primary structure
• protein
• protein synthesis
• regeneration
• synthesis
• transcription

• Department of Molecular Genetics, Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria

  Asen A. Hadjiolov

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