Sphingolipids in Disease

1. Front Matter

   Pages i-viii

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2. Sphingolipids in Cancer

   1. Front Matter

      Pages 1-1

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   2. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance

      • Shanmugam Panneer Selvam, Besim Ogretmen

      Pages 3-27

   3. Using ASMase Knockout Mice to Model Human Diseases

      • Guoqiang Hua, Richard Kolesnick

      Pages 29-54

   4. New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer

      • Susan Pyne, Nigel J. Pyne

      Pages 55-71

   5. Sphingolipids and Response to Chemotherapy

      • Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard

      Pages 73-91

   6. Lung Cancer and Lung Injury: The Dual Role of Ceramide

      • Tzipora Goldkorn, Samuel Chung, Simone Filosto

      Pages 93-113

   7. Sphingolipids’ Role in Radiotherapy for Prostate Cancer

      • Carla Hajj, Adriana Haimovitz-Friedman

      Pages 115-130

3. Sphingolipids in Cardio-Reno-vascular Diseases

   1. Front Matter

      Pages 131-131

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   2. Sphingolipid Metabolism and Atherosclerosis

      • Xian-Cheng Jiang, Jing Liu

      Pages 133-146

   3. Cardiovascular Effects of Sphingosine-1-Phosphate (S1P)

      • Bodo Levkau

      Pages 147-170

   4. Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease

      • Pin-Lan Li, Yang Zhang

      Pages 171-197

4. Sphingolipids in Inflammation, Infection and Lung Diseases

   1. Front Matter

      Pages 199-199

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   2. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity

      • Taimur Abbasi, Joe G. N. Garcia

      Pages 201-226

   3. Sphingolipids in Acute Lung Injury

      • Stefan Uhlig, Yang Yang

      Pages 227-246

   4. The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases

      • Irina Petrache, Daniela N. Petrusca

      Pages 247-264

   5. Ceramide in Cystic Fibrosis

      • Heike Grassmé, Joachim Riethmüller, Erich Gulbins

      Pages 265-274

   6. Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

      • K. Alexa Orr Gandy, Lina M. Obeid

      Pages 275-303

   7. Bacterial Infections and Ceramide

      • Heike Grassmé, Katrin Anne Becker

      Pages 305-320

   8. Viral Infections and Sphingolipids

      • Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies

      Pages 321-340

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This  book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology  as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.   ​

• Cancer
• Ceramide
• Infectious Disease
• Sphingolipids
• Sphingosine 1-Phosphate
• Sphingosine Kinase

• , Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany

  Erich Gulbins

• Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA

  Irina Petrache

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