Pain Control

1. Front Matter

   Pages i-viii

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2. Emerging Concepts of Pain Therapy Based on Neuronal Mechanisms

   • Hans-Georg Schaible

   Pages 1-14

3. The Pharmacology of Nociceptor Priming

   • Ram Kandasamy, Theodore J. Price

   Pages 15-37

4. Sodium Channels and Pain

   • Abdella M. Habib, John N. Wood, James J. Cox

   Pages 39-56

5. Role of Nerve Growth Factor in Pain

   • Kazue Mizumura, Shiori Murase

   Pages 57-77

6. Central Sensitization in Humans: Assessment and Pharmacology

   • Lars Arendt-Nielsen

   Pages 79-102

7. Nitric Oxide-Mediated Pain Processing in the Spinal Cord

   • Achim Schmidtko

   Pages 103-117

8. The Role of the Endocannabinoid System in Pain

   • Stephen G. Woodhams, Devi Rani Sagar, James J. Burston, Victoria Chapman

   Pages 119-143

9. The Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain

   • Elizabeth Amy Old, Anna K. Clark, Marzia Malcangio

   Pages 145-170

10. Plasticity of Inhibition in the Spinal Cord

    • Andrew J. Todd

    Pages 171-190

11. Modulation of Peripheral Inflammation by the Spinal Cord

    • Linda S. Sorkin

    Pages 191-206

12. The Relationship Between Opioids and Immune Signalling in the Spinal Cord

    • Jacob Thomas, Sanam Mustafa, Jacinta Johnson, Lauren Nicotra, Mark Hutchinson

    Pages 207-238

13. The Role of Proteases in Pain

    • Jason J. McDougall, Milind M. Muley

    Pages 239-260

14. Amygdala Pain Mechanisms

    • Volker Neugebauer

    Pages 261-284

15. Itch and Pain Differences and Commonalities

    • Martin Schmelz

    Pages 285-301

16. Back Matter

    Pages 303-309

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This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.

• calcium channels
• drug therapy
• pain control
• pain mechanisms
• sodium channels
• spinal cord

• Institute of Physiology/Neurophysiology, Jena University Hospital, Jena, Germany

  Hans-Georg Schaible

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