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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Drug Manipulation Strategies and Vehicle Effects

  • Book
  • © 2015

Overview

Editors:
  1. Nina Dragicevic

    1. Apoteka "Beograd", Belgrade, Serbia

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    You can also search for this editor in PubMed   Google Scholar

  2. Howard I. Maibach

    1. San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Describes in detail enhancement methods in the field of dermal/transdermal drug delivery

  • Covers both the best known and the most recently developed chemical and physical methods

  • Edited by a team of the most experienced scientists in the field

  • Invaluable for researchers, pharmaceutical scientists, practitioners, and students

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. The Skin

    1. Front Matter

      Pages 1-1
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    2. Skin Deep: The Basics of Human Skin Structure and Drug Penetration

      • Keng Wooi Ng, Wing Man Lau
      Pages 3-11

    3. Epidermal Lipids and the Intercellular Pathway

      • Philip W. Wertz
      Pages 13-18

    4. The Importance of Stratum Corneum Lipid Organization for Proper Barrier Function

      • Annett Schroeter, Adina Eichner, Josefin Mueller, Reinhard H. H. Neubert
      Pages 19-38

    5. Molecular Structure and Function of the Skin Barrier

      • Lars Norlén
      Pages 39-42

    6. The Increasing Importance of the Hair Follicle Route in Dermal and Transdermal Drug Delivery

      • Alexa Patzelt, Jürgen Lademann
      Pages 43-53

    7. The Correlation Between Transepidermal Water Loss and Percutaneous Absorption

      • Jacquelyn Levin, Howard I. Maibach
      Pages 55-67

    8. Influence of Excipients on Two Elements of the Stratum Corneum Barrier: Intercellular Lipids and Epidermal Tight Junctions

      • Laurène Roussel, Rawad Abdayem, Elodie Gilbert, Fabrice Pirot, Marek Haftek
      Pages 69-90

  3. Penetration Enhancement Techniques in Skin Delivery

    1. Front Matter

      Pages 91-91
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    2. Targets in Dermal and Transdermal Delivery and Classification of Penetration Enhancement Methods

      • Jelena Predic Atkinson, Howard I. Maibach, Nina Dragicevic
      Pages 93-108

    3. Formulation Effects in Percutaneous Absorption

      • Rina Kuswahyuning, Jeffrey E. Grice, Hamid R. Moghimi, Michael S. Roberts
      Pages 109-134

  4. Drug Manipulation Strategies in Penetration Enhancement

    1. Front Matter

      Pages 135-135
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    2. Selection of a Proper Prodrug for Penetration Enhancement

      • Kenneth B. Sloan, Jennifer Synovec, Scott C. Wasdo
      Pages 137-150

    3. Transdermal Drug Delivery Systems Using Supersaturation

      • Vishwas Rai, Lakshmi Raghavan
      Pages 151-161

    4. Eutectic Systems for Penetration Enhancement

      • Stuart A. Jones, Sarah Fiala, Marc B. Brown
      Pages 163-173

    5. Formation of Ion Pairs and Complex Coacervates

      • Liang Fang, Honglei Xi, Dongmei Cun
      Pages 175-187

    6. Formulation of Drug-Cyclodextrin Complexes

      • Thorsteinn Loftsson
      Pages 189-205

  5. Influence of Vehicle Effects in Penetration Enhancement

    1. Front Matter

      Pages 207-207
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    2. Dermal and Transdermal Formulations: How They Can Affect the Active Compound

      • Jessica Stahl
      Pages 209-220
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Keywords

About this book

This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse physical methods used in penetration enhancement, such as sonophoresis, iontophoresis, electroporation, microporation, laser ablation, and microneedles. Determination of drug penetration is covered in the final volume, with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. This edition of Percutaneous Penetration Enhancers will be an invaluable resource for researchers, pharmaceutical scientists, practitioners, and also students.

Reviews

“This book details the fundamental principles of drug design and formulations to penetrate the skin. It is a very detailed book designed for specialists working in this area of drug delivery technology. …  is designed for pharmaceutical scientists working in industry and academia, as well as younger researchers exploring the world of drug delivery via this route.” (Patrick J. McDonnell, Doody’s Book Reviews, April, 2016)

Editors and Affiliations

  • Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  • San Francisco, USA

    Howard I. Maibach

About the editors

Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively, with a total of more than 2,500 publications as lead or co-author. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He has also been the recipient of numerous honors, both within the United States and overseas.

Nina Dragićević-Ćurić graduated from the University of Belgrade, Faculty of Pharmacy in 1999 and subsequently obtained an MSc and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical Technology from the University of Belgrade and the Friedrich-Schiller University, Jena, respectively. Dr. Dragićević-Ćurić is an accredited Specialist in Pharmaceutical Technology. From 2007 to 2013 she was responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company Apoteka "Beograd" in Belgrade, and in 2013 she was appointed Director of the Production Department in the same company. She has published in a variety of international journals.

 

Bibliographic Information

  • Book Title: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

  • Book Subtitle: Drug Manipulation Strategies and Vehicle Effects

  • Editors: Nina Dragicevic, Howard I. Maibach

  • DOI: https://doi.org/10.1007/978-3-662-45013-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-662-45012-3Published: 30 April 2015

  • Softcover ISBN: 978-3-662-51166-4Published: 17 October 2016

  • eBook ISBN: 978-3-662-45013-0Published: 04 April 2015

  • Edition Number: 1

  • Number of Pages: XVI, 341

  • Number of Illustrations: 80 b/w illustrations, 38 illustrations in colour

  • Topics: Dermatology, Pharmacology/Toxicology

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