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Reducing Drug Attrition

  • Book
  • © 2014

Overview

Editors:
  1. James R. Empfield

    1. Vertex Pharmaceuticals, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Michael P Clark

    1. Vertex Pharmaceuticals, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Overview chapters introduce the newcomer to the topic covered
  • Series covers hot topics of frontier research summarized by reputed scientists in the field
  • Volumes are useful and of relevance for a long period of time

Part of the book series: Topics in Medicinal Chemistry (TMC, volume 11)

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Table of contents (4 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Target Selection and Validation in Drug Discovery

    • Clive G. Jackson
    Pages 1-72

  3. Optimizing Pharmacokinetic Properties and Attaining Candidate Selection

    • Keith W. Ward
    Pages 73-95

  4. The Role of Biotransformation Studies in Reducing Drug Attrition

    • Douglas K. Spracklin, Amit S. Kalgutkar, Angus N. R. Nedderman
    Pages 97-137

  5. Reducing Drug Attrition: Safety Pharmacology

    • Peter Siegl
    Pages 139-158

  6. Back Matter

    Pages 159-162
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About this book

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Editors and Affiliations

  • Vertex Pharmaceuticals, Boston, USA

    James R. Empfield, Michael P Clark

Bibliographic Information

  • Book Title: Reducing Drug Attrition

  • Editors: James R. Empfield, Michael P Clark

  • Series Title: Topics in Medicinal Chemistry

  • DOI: https://doi.org/10.1007/978-3-662-43914-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-662-43913-5Published: 09 December 2014

  • Softcover ISBN: 978-3-662-50567-0Published: 23 August 2016

  • eBook ISBN: 978-3-662-43914-2Published: 27 November 2014

  • Series ISSN: 1862-2461

  • Series E-ISSN: 1862-247X

  • Edition Number: 1

  • Number of Pages: XV, 162

  • Number of Illustrations: 16 b/w illustrations, 6 illustrations in colour

  • Topics: Medicinal Chemistry, Pharmacology/Toxicology

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