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Human Hematopoiesis in SCID Mice

  • Book
  • © 1995

Overview

Authors:
  1. Maria-Grazia Roncarolo

    1. DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, USA

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  2. Bruno Péault

    1. Institut d’Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, France

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  3. Reiko Namikawa

    1. DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, USA

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Part of the book series: Medical Intelligence Unit (MIU.LANDES)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Human Hematopoietic Development

    1. Front Matter

      Pages 1-1
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    2. Landmarks in the Unnatural History of SCID-hu Mice

      • Bruno Péault
      Pages 3-13

    3. Detection of Human Hematopoietic Stem Cells in SCID-hu Mice

      • Anne H. M. Galy, Benjamin P. Chen
      Pages 15-34

    4. Human T-Cell Development in SCID-hu Mice

      • Maria-Grazia Roncarolo, Dominique Schols, Reiko Namikawa, Jan E. de Vries
      Pages 35-52

    5. Effects of Cytokine Administration on Human Hematopoiesis in SCID-hu Mice

      • Marcus O. Muench, Maria-Grazia Roncarolo, Reiko Namikawa
      Pages 53-68

  3. Human Immune Responses

    1. Front Matter

      Pages 69-69
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    2. Human Humoral Immunity in SCID Mice

      • Mohammad R. Abedi, Lennart Hammarström, Birger Christensson, C. I. Edvard Smith
      Pages 71-103

    3. Antigen-Specific Immune Responses in Human/Mouse Chimeras

      • Yair Reisner
      Pages 105-126

  4. Models for Human Hematopoietic Diseases

    1. Front Matter

      Pages 127-127
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    2. The Hematopathology of HIV-1 Disease: Experimental Analysis in Vivo

      • Joseph M. Mccune, Hideto Kaneshima
      Pages 129-156

    3. SCID-hu Mice as a Model for the Study of Human Malignancies

      • Reiko Namikawa
      Pages 157-170

    4. SCID Mice as a Model for Human Leukemias

      • Alessandra Cesano, Daniela Santoli
      Pages 171-196

    5. Human Hematopoiesis in SCID Mice

      • Josef Vormoor, Tsvee Lapidot, André Larochelle, John E. Dick
      Pages 197-212

  5. Back Matter

    Pages 213-225
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Keywords

About this book

This book presents essential information on the use of the immunodeficient C.B.-17 SCID/SCID mouse for studying human hematopoiesis in vivo. Because of the lack of both humoral and cellular immunity, this mouse can be a unique host for implantation of human hematopoietic tissue using different methods. In the first section, in vivo development of human hematopoietic stem cells and differentiation of human T cells are described. In addition, the effects of growth factors and toxic agents of human hematopoiesis are described. The second section contains chapters in which the human immune responses in the SCID mouse are reviewed. The third section covers SCID mouse models to study human infectious diseases, leukemias and genetic disorders.

Authors and Affiliations

  • DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, USA

    Maria-Grazia Roncarolo, Reiko Namikawa

  • Institut d’Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, France

    Bruno Péault

Bibliographic Information

  • Book Title: Human Hematopoiesis in SCID Mice

  • Authors: Maria-Grazia Roncarolo, Bruno Péault, Reiko Namikawa

  • Series Title: Medical Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-22008-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1995

  • Softcover ISBN: 978-3-662-22010-8Published: 20 November 2013

  • eBook ISBN: 978-3-662-22008-5Published: 21 November 2013

  • Series ISSN: 1080-3645

  • Edition Number: 1

  • Number of Pages: XVI, 225

  • Number of Illustrations: 41 b/w illustrations, 36 illustrations in colour

  • Additional Information: Jointly published with R.G. Landes, Biomedical Publishers, Austin, USA

  • Topics: Molecular Medicine, Immunology

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