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Genetic Mechanisms in Multiple Endocrine Neoplasia Type 2

  • Book
  • © 1996

Overview

Authors:
  1. Barry D. Nelkin

    1. Johns Hopkins Oncology Center, School of Medicine, Johns Hopkins University, Baltimore, USA

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Part of the book series: Medical Intelligence Unit (MIU.LANDES)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xi
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  2. Clinical Manifestations of Multiple Endocrine Neoplasia Type 2

    • Douglas W. Ball
    Pages 1-20

  3. Mutations in Ret in MEN 2

    • B. A. J. Ponder, M. A. Pierotti
    Pages 21-35

  4. Intracellular Signaling by the ret Tyrosine Kinase

    • Alfredo Fusco, Giancarlo Vecchio, Nina A. Dathan, Francesca Carlomagno, Pier Paolo Di Fiore, Massimo Santoro
    Pages 37-59

  5. Mechanisms of Growth Factor-Mediated Signal Transduction in PC12 Cells

    • Michael P. Myers, Kenneth D. Swanson, Gary Landreth
    Pages 61-98

  6. Origin of Adrenal Chromaffin Cells from the Neural Crest

    • Kristine S. Vogel
    Pages 99-118

  7. The Adrenal Medulla in MEN 2

    • Arthur S. Tischler, Ronald A. DeLellis
    Pages 119-136

  8. Neuronal Properties of Thyroid C-Cell Tumor Lines

    • Andrew F. Russo, Thomas M. Lanigan
    Pages 137-161

  9. Progression of Medullary Thyroid Carcinoma

    • Barry D. Nelkin
    Pages 163-182

  10. Molecular Events in the Development and Progression of Medullary Thyroid Cancer and Pheochromocytoma

    • Jeffrey F. Moley
    Pages 183-193

  11. Conclusion

    • Barry D. Nelkin
    Pages 195-198

  12. Back Matter

    Pages 199-201
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Keywords

About this book

This book examines what is known about the molecular biology of multiple endocrine neoplasia, type 2 (MEN2). Mutations and alterations in gene expressions and signal transduction are placed in the context of their effects on the biology of the thyroid and adrenal cells which generate cancers in MEN2. Thus, this volume addresses the ret mutations, the effects these mutations may have on signal transduction, and developmental and neurobiological aspects of the cells affected of MEN2, and provides the basic researcher - in genetics, signal transduction, cell transformation, developmental or neurobiology - with a better understanding of how the knowledge generated by each of these fields intercalates within the overall biology of MEN2.

Authors and Affiliations

  • Johns Hopkins Oncology Center, School of Medicine, Johns Hopkins University, Baltimore, USA

    Barry D. Nelkin

Bibliographic Information

  • Book Title: Genetic Mechanisms in Multiple Endocrine Neoplasia Type 2

  • Authors: Barry D. Nelkin

  • Series Title: Medical Intelligence Unit

  • DOI: https://doi.org/10.1007/978-3-662-21948-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-662-21950-8Published: 13 November 2013

  • eBook ISBN: 978-3-662-21948-5Published: 21 November 2013

  • Series ISSN: 1080-3645

  • Edition Number: 1

  • Number of Pages: XI, 201

  • Number of Illustrations: 33 b/w illustrations

  • Additional Information: Jointly published with R.G. Landes. Biomedical Publishers, Austin, USA

  • Topics: Cancer Research, Cell Biology

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