Immunological Aspects of Viral Oncolysis

1. Front Matter

   Pages i-vi

   PDF

2. Introduction

   • Jean Lindenmann, Paul A. Klein

   Pages 1-3

3. Tumor Immunity. A Brief Review

   • Jean Lindenmann, Paul A. Klein

   Pages 3-9

4. Viral Oncolysis: A Brief Review

   • Jean Lindenmann, Paul A. Klein

   Pages 9-13

5. Natural Resistance of Mice to Various Viruses

   • Jean Lindenmann, Paul A. Klein

   Pages 13-18

6. Tumor Immunity following Viral Oncolysis

   • Jean Lindenmann, Paul A. Klein

   Pages 18-66

7. General Discussion

   • Jean Lindenmann, Paul A. Klein

   Pages 66-75

8. Summary

   • Jean Lindenmann, Paul A. Klein

   Pages 75-75

9. Back Matter

   Pages 75-86

   PDF

mouse tissue alloantigen detected by this procedure. An antigen of cross-reacting specificity was revealed in tissue extracts of many other animal species. We next wanted to learn more about the antigen responsible for induction of postoncolytic immunity. Extracts from virus-infected tumors were immunogenic, and both active and inactive fractions of such extracts were obtained. The growth of the virus in the tumor cells was studied with the electron microscope, in the hope that this might shed some light on the manner in which viral infection transforms a poorly immunogenic tumor into a highly immunogenic one. We consider none of the questions which our work has raised as definitely solved. In fact, we are still working on many of the aspects alluded to above. When we embarked on a study of postoncolytic immunity, we were supported in this endeavor by our lack of experience in the fields of transplantation and tumor immunology.

• growth
• immunology
• neoplasm
• transplantation
• tumor
• virus

• Institute for Medical Microbiology, The University of Zurich, Switzerland

  Jean Lindenmann

• Department of Microbiology, College of Medicine, University of Florida, Gainesville, USA

  Paul A. Klein

Policies and ethics