Pathobiology of Human Germ Cell Neoplasia

1. Front Matter

   Pages I-XII

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2. Overview

   1. Pathobiology of Human Germ Cell Neoplasia

      • I. Damjanov

      Pages 1-19

3. Cells of Origin

   1. Carcinoma in Situ of the Testis: Possible Origin, Clinical Significance, and Diagnostic Methods

      • A. Giwercman, J. Müller, N. E. Skakkebæk

      Pages 21-36

   2. Characterization of Precancerous and Neoplastic Human Testicular Germ Cells

      • H. Walt, P. Emmerich, A. Jauch, C. D. DeLozier-Blanchet

      Pages 37-44

   3. Cytogenetic Investigation of Gonadal Carcinomas in Situ in Syndromes of Abnormal Sexual Differentiation

      • I. Vorechovsky, K. Mazanec

      Pages 45-49

4. Cell Lines

   1. Human Embryonal Carcinoma and Yolk Sac Carcinoma in Vitro: Cell Lineage Relationships and Possible Paracrine Growth Regulatory Interactions

      • M. F. Pera, S. Cooper, W. Bennet, I. Crawford-Bryce

      Pages 51-58

   2. Biochemical Analysis and Cellular Location of the GCTM-2 Antigen in Embryonal Carcinoma and in Other Tumour Cell Lines

      • M. D. Mason, M. F. Pera

      Pages 59-61

5. Differentiation Antigens

   1. The Surface Antigen Phenotype of Human Embryonal Carcinoma Cells: Modulation Upon Differentiation and Viral Infection

      • P. W. Andrews, J. Marrink, G. Hirka, A. von Keitz, D. Th. Sleijfer, E. Gönczöl

      Pages 63-83

   2. Lactate Dehydrogenase Isoenzyme 1 in Testicular Germ Cell Tumors

      • F. E. von Eyben, O. Blaabjerg, P. H. Petersen, S. Mommsen, E. L. Madsen, F. Kirpekar et al.

      Pages 85-92

   3. Expression of Developmentally Regulated Genes in Embryonal Carcinoma Cells

      • P. Dráber

      Pages 93-100

6. Chromosomal Studies

   1. Cytogenetic Studies of Testicular Germ Cell Tumors: Pathogenetic Relevance

      • S. M. M. J. Castedo, J. W. Oosterhuis, B. de Jong

      Pages 101-106

   2. Isochromosome (12p) in Germ Cell Tumors

      • P. Dal Cin, H. Van Den Berghe

      Pages 107-111

7. Molecular Genetics

   1. Molecular Analysis of Isochromosome 12p in Testicular Germ Cell Tumors

      • A. Geurts van Kessel, R. Suijkerbuijk, B. de Jong, J. W. Oosterhuis

      Pages 113-118

   2. Analysis of Chromosome 12 Abnormalities in Male Germ Cell Cancers

      • E. Dmitrovsky, E. Rodriguez, F. Samaniego, V. E. Reuter, W. H. Miller Jr., N. L. Geller et al.

      Pages 119-123

   3. Frequent Occurrence of Activated ras Oncogenes in Seminomas but Not in Nonseminomatous Germ Cell Tumors

      • M. P. Mulder, W. Keijzer, T. A. W. Splinter, J. L. Bos

      Pages 125-131

   4. Differential Activation of Homeobox Genes by Retinoic Acid in Human Embryonal Carcinoma Cells

      • L. Bottero, A. Simeone, L. Arcioni, D. Acampora, P. W. Andrews, E. Boncinelli et al.

      Pages 133-143

8. Growth Factors and Their Receptors

   1. Growth Factors and the Control of Human Teratoma Cell Proliferation

      • W. Engström, M. Tally, M. Granerus, E. P. Hedley, P. Schofield

      Pages 145-153

   2. Role of Heparin-Binding Growth Factors in Embryonic Tumors

      • E. J. J. van Zoelen

      Pages 155-163

   3. Growth Factors and Receptors During Differentiation: A Comparison of Human and Murine Embryonal Carcinoma Cell Lines

      • C. L. Mummery, S. M. Weima

      Pages 165-182

   4. Growth Factors in Human Germ Cell Cancer

      • W. H. Miller Jr., E. Dmitrovsky

      Pages 183-189

Pathobiology of Human Germ Cell Neoplasia is a state-of-the-art compendium on a very recent branch of tumor biology. It offers an awareness and understanding of germ cell tumors: from the earliest stages to their va- rious differentiations. Original data for this volume was supplied by experts in the fields of pathology, developmental biology, genetics, molecular biology and other related fields. This compilation of knowledge provides information necessary to persons working in clinical and preclinical areas.

• Keimzelltumor
• Pathobiologie
• cancer
• carcinoma
• cell
• embryo
• genetics
• infection
• molecular biology
• molecular genetics
• pathology
• testis
• tumor

• Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

  J. Wolter Oosterhuis

• Department of Gynecology and Obstetrics, Research Division of Gynecology, University Hospital, Zürich, Switzerland

  Heinrich Walt

• Department of Pathology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

  Ivan Damjanov

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