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Preoperative (Neoadjuvant) Chemotherapy

  • Conference proceedings
  • © 1986

Overview

Editors:
  1. Joseph Ragaz

    1. Cancer Control Agency of British Columbia, Vancouver, Canada

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  2. Pierre R. Band

    1. Cancer Control Agency of British Columbia, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  3. James H. Goldie

    1. Cancer Control Agency of British Columbia, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 103)

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Table of contents (18 papers)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Clinical and Scientific Considerations in Preoperative (Neoadjuvant) Chemotherapy

    • E. Frei III, D. Miller, J. R. Clark, B. G. Fallon, T. J. Ervin
    Pages 1-5

  3. Experimental Adjuvant Chemotherapy: An Overview

    • H. E. Skipper
    Pages 6-29

  4. Theoretical Considerations Regarding the Early Use of Adjuvant Chemotherapy

    • J. H. Goldie, A. J. Coldman
    Pages 30-35

  5. Experimental Preoperative Chemotherapy

    • L. M. van Putten
    Pages 36-40

  6. Implications of Certain Cell Kinetic and Biological Parameters for Preoperative Chemotherapy

    • B. T. Hill
    Pages 41-53

  7. Adjuvant Therapy for Breast Cancer: A Brief Overview of the NSABP Experience and Some Thoughts on Neoadjuvant Chemotherapy

    • B. Fisher
    Pages 54-68

  8. Factors Affecting the Development of Permanent Drug Resistance and Its Impact upon Neoadjuvant Chemotherapy

    • A. J. Coldman, J. H. Goldie
    Pages 69-78

  9. Impact of Preoperative Chemotherapy for the Surgeon

    • R. M. Baird, P. A. Rebbeck
    Pages 79-84

  10. Preoperative (Neoadjuvant) Chemotherapy for Breast Cancer: Outline of the British Columbia Trial

    • J. Ragaz
    Pages 85-94

  11. Perioperative Adjuvant Chemotherapy of Breast Cancer: The Scandinavian Experience

    • R. Nissen-Meyer, H. Host, K. Kjellgren, B. Mansson, T. Norin
    Pages 95-102

  12. Perioperative and Conventionally Timed Chemotherapy in Operable Breast Cancer: The Ludwig Breast Cancer Study V

    • A. Goldhirsch, R. Gelber
    Pages 103-112

  13. Neoadjuvant Chemotherapy in the Conservative Management of Breast Cancers: Study of 143 Patients

    • C. I. Jacquillat, M. Weil, G. Auclerc, M. Sellami, M. F. Auclerc, D. Khayat et al.
    Pages 113-119

  14. Preliminary Results of Preoperative Chemotherapy with a Combination of Platinum-Bleomycin Administered in 5-Day Cycles in Carcinoma of the Bronchus

    • J. Clavier, L. Israël, G. Nouvet, Y. Raut, J.-J Gres, J.-F Morère et al.
    Pages 120-123

  15. Impact of Primary Site of Stage III and IV Squamous Cell Carcinomas of the Head and Neck on 7-Year Survival Figures Following Initial Non-Cisplatin-Containing Combination Chemotherapy

    • L. A. Price, B. T. Hill
    Pages 124-134

  16. Chemotherapy with or Without Anticoagulation as Initial Management of Patients with Operable Colorectal Cancer: A Prospective Study with at Least 5 Years Follow-up

    • A. N. Papaioannou, A. P. Polychronis, J. A. Kozonis, J. Nomicos, M. Tsamouri, G. A. Plataniotis et al.
    Pages 135-141

  17. Preoperative Chemotherapy for Gastric Cancer: A Prospective Study with at Least 1 Year Follow-up

    • A. N. Papaioannou, J. A. Kozonis, A. P. Polychronis, J. Nomicos, G. A. Plataniotis, J. K. Papageorgiou
    Pages 142-147

  18. Neoadjuvant Chemotherapy for Osteogenic Sarcoma: A Model for the Treatment of Other Highly Malignant Neoplasms

    • G. Rosen
    Pages 148-157

  19. Summary of Preoperative (Neoadjuvant) Chemotherapy

    • J. M. Goldie, P. Band, J. Ragaz
    Pages 158-159

  20. Back Matter

    Pages 160-162
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Keywords

About this book

Despite recent advances in adjuvant therapies of cancer, the regi­ mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre­ operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur­ gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor­ tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re­ fined individual approaches to the planning of postoperative adju­ vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

Editors and Affiliations

  • Cancer Control Agency of British Columbia, Vancouver, Canada

    Joseph Ragaz, Pierre R. Band, James H. Goldie

Bibliographic Information

  • Book Title: Preoperative (Neoadjuvant) Chemotherapy

  • Editors: Joseph Ragaz, Pierre R. Band, James H. Goldie

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-82671-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-642-82673-3Published: 14 March 2012

  • eBook ISBN: 978-3-642-82671-9Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 162

  • Number of Illustrations: 2 b/w illustrations

  • Topics: Oncology, Pharmacology/Toxicology, Internal Medicine, Surgery

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