Endocrine Treatment of Breast Cancer

1. Front Matter

   Pages I-XIX

   PDF

2. Introduction

   1. Introduction

      • B. Henningsen

      Pages 1-2

3. Improved Biochemical Characterization of Breast Cancer

   1. Improved Biochemical Characterization of Breast Cancer as a Guide to Hormonal Treatment

      • R. K. Wagner, P. W. Jungblut

      Pages 3-10

   2. Steroid Receptor Determinations in Mammary Carcinoma in Women

      • B. Runnebaum, K. Klinga

      Pages 11-13

   3. Steroid Receptor Determination by Means of Agar Gel Electrophoresis

      • D. Kummer

      Pages 14-15

   4. Estrogen Receptor Determination Predicts Response to Tamoxifen Therapy

      • J. C. Allegra, M. E. Lippman

      Pages 16-19

   5. Estrogen Receptor Status and the Disease-Free Interval in Breast Cancer

      • J. C. Allegra, M. E. Lippman

      Pages 20-25

   6. Clinical Predictive Criteria for Response to Endocrine Treatment and the Receptor Status

      • H. Maass, W. Jonat

      Pages 26-29

4. Antiestrogens in Experimental Breast Cancer

   1. Anti-Oestrogen Action in Experimental Breast Cancer

      • V. C. Jordan, K. E. Naylor, C. J. Dix, G. Prestwich

      Pages 30-44

   2. Studies on Mechanisms of Estrogen and Antiestrogen Action in Human Breast Cancer

      • K. B. Horwitz, W. L. McGuire

      Pages 45-58

   3. Human Breast Cancer in Nude Mice: A Model for Testing Endocrine Treatment

      • R.-T. Michel, H. Schmidt-Matthiesen, G. Bastert, H. P. Fortmeyer

      Pages 59-68

   4. A Hormone-Dependent Human Breast Cancer Cell Line Grown in Defined Medium

      • M. E. Lippman, J. C. Allegra, J. S. Strobl

      Pages 69-79

   5. Endocrine and Cytostatic Treatment of Experimental Mammary Cancer

      • H. H. Fiebig, D. Schmähl

      Pages 80-95

   6. The Direct Inhibition of Prostaglandin Synthetase of Human Breast Cancer Tumour Tissue by Tamoxifen

      • G. A. F. Ritchie

      Pages 96-101

5. Endocrine Treatment of Advanced Breast Cancer

   1. Endocrine Treatment of Advanced Breast Cancer

      • H. Maass, W. Jonat

      Pages 102-111

   2. Principles and Indications of Endocrine Treatment of Advanced Breast Cancer

      • H. T. Mouridsen, T. Palshof

      Pages 112-117

   3. Ablation of the Hypophysis by Radioactive Gold in Metastatic Mammary Carcinoma

      • W. Piotrowski

      Pages 118-121

   4. Anti-Oestrogens: An Alternative to Ablative Endocrine Therapy?

      • B. Henningsen

      Pages 122-124

6. Anti-Oestrogens in the Treatment of Advanced Breast Cancer

   1. Tamoxifen in Advanced Breast Cancer: Experience of the SAKK (Schweizerische Arbeitsgruppe für Klinische Krebsforschung — Swiss Cooperative Oncology Group)

      • W. P. Jungi, P. Alberto, F. Cavalli

      Pages 125-133

   2. Therapeutic Effect of Tamoxifen Related to Estrogen Receptor Level

      • C. Rose, S. M. Thorpe, J. Løber, J. L. Dænfeldt, T. Palshof, H. T. Mouridsen

      Pages 134-141

Progress in basic research has made it necessary to redetermine the possibility of classic endocrine therapy for the treatment of patients with breast cancer. Exemplary, close cooperation between biochemis­ try and animal and clinical research led to a truly interdisciplinary and international exchange of ideas and experience at a symposium held in autumn 1978 in Heidelberg. We owe our thanks to ICI-Pharma for the kind support of this sym­ posIUm. The participation of Charles Huggins in the meeting as honorary chairman signified to all participants the meaning of this joint endeavour. It was the same Charles Huggins who through experimental work laid the foundation stone for endocrine ther­ apy of prostate and breast cancer, and who applied his findings clinically. Thousands of patients owe to him relief from their suffering. He contributed greatly to the attempt to find and stabilize the endocrine therapy for breast cancer, for which we thank him sincerely. We hope that the following contributions will similarly serve the well-being of our patients.

• Brustkrebs
• Hormontherapie
• Tamoxifenum
• child
• hormone
• hormone therapy

• Chirurgische Klinik, Klinikum der Universität Heidelberg, Heidelberg 1, Germany

  B. Henningsen, F. Linder

• ICI-Pharma, Clinical Research, Heidelberg 1, Germany

  C. Steichele

Policies and ethics