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Hemopoietic Colonies

In Vitro Cloning of Normal and Leukemic Cells

  • Book
  • © 1977

Overview

Authors:
  1. Donald Metcalf

    1. Cancer Research Unit, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 61)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-ix
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  2. Historical Introduction

    • Donald Metcalf
    Pages 1-4

  3. An Outline of Hemopoiesis and Current Terminology

    • Donald Metcalf
    Pages 5-11

  4. Techniques for the Clonal Culture of Hemopoietic Cells in Semisolid Medium

    • Donald Metcalf
    Pages 12-35

  5. General Features of Hemopoietic Colony Formation

    • Donald Metcalf
    Pages 36-56

  6. Neutrophil and Macrophage Colony Formation by Normal Cells

    • Donald Metcalf
    Pages 57-98

  7. Colony Formation by Myeloid Leukemic Cells

    • Donald Metcalf
    Pages 99-131

  8. GM-Colony Formation in Myeloproliferative Disorders

    • Donald Metcalf
    Pages 132-139

  9. Eosinophil Colony Formation

    • Donald Metcalf
    Pages 140-149

  10. Megakaryocyte Colony Formation

    • Donald Metcalf
    Pages 150-159

  11. Erythroid Colony Formation

    • Donald Metcalf
    Pages 160-169

  12. Normal Mouse and Human Lymphocyte Colonies

    • Donald Metcalf
    Pages 170-186

  13. Neoplastic Lymphoid and Plasmacytoma Colonies

    • Donald Metcalf
    Pages 187-194

  14. Hemopoietic Stromal Colonies

    • Donald Metcalf
    Pages 195-199

  15. General Discussion

    • Donald Metcalf
    Pages 200-205

  16. Back Matter

    Pages 206-230
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Keywords

About this book

The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been successfully cultured in vitro. The time seemed appropriate to write a short general account of this exciting new area of hematology, emphasizing particularly the potential value of these new techniques for direct studies on patients with leukemia and allied diseases. I had hoped to refer to, or at least record, every paper published in this field, but the literature proved to be larger than I had realized, and furthermore, some areas were so active that chapters had to be rewritten over a period of less than a year. I regret that ยทwhat follows is an incomplete account and no doubt, by the time this book becomes available, the material will be even more out of date. However, I have described the basic techniques in some detail and have tried, where possible, to explain how and why the techniques can fail. It is already possible to see patterns, perhaps even principles, emerging from this work which may well be applicable to other cell populations. These have been emphasized in the text in an attempt to make this review as creative as possible.

Authors and Affiliations

  • Cancer Research Unit, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Donald Metcalf

Bibliographic Information

  • Book Title: Hemopoietic Colonies

  • Book Subtitle: In Vitro Cloning of Normal and Leukemic Cells

  • Authors: Donald Metcalf

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-81140-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin ยท Heidelberg 1977

  • Softcover ISBN: 978-3-642-81142-5Published: 11 January 2012

  • eBook ISBN: 978-3-642-81140-1Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 230

  • Number of Illustrations: 17 b/w illustrations

  • Topics: Oncology, Hematology

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