Cancer Active Immunotherapy

1. Front Matter

   Pages I-XV

   PDF

2. Introduction and Definitions

   • Georges Mathé

   Pages 1-4

3. Biological Basis:Tumour Associated Antigens, the Immune Machinery, and Its Behaviour Concerning Cancer Cells

   • Georges Mathé

   Pages 5-75

4. Systemic Active Immunotherapy

   • Georges Mathé

   Pages 76-142

5. Cancer Local Active Immunotherapy

   • Georges Mathé

   Pages 143-152

6. Towards Immunoprophylaxis

   • Georges Mathé

   Pages 153-168

7. Towards Immune Restoration

   • Georges Mathé

   Pages 169-207

8. Developmental Pharmacology

   • Georges Mathé

   Pages 208-294

9. Toxicology and Adverse Effects

   • Georges Mathé

   Pages 295-319

10. Mechanisms of Favourable and Adverse Effects and of Failures

    • Georges Mathé

    Pages 320-363

11. Conclusion: Immunotherapy and Immunorestoration Today in the Strategy of Cancer Treatment; Their Perspectives and that of Immunoprophylaxis

    • Georges Mathé

    Pages 364-380

12. Appendix: Towards Monitoring the Immunological Status and Its Modification Induced by Immunotherapy, Immunorestoration or Immunoprophylaxis

    • Georges Mathé

    Pages 381-402

13. Back Matter

    Pages 403-408

    PDF

I would like to thank all my co-workers who have collaborated with me, from 1963 until now, in biological and clinical research in the field of cancer active immunotherapy, of its immuno­ prevention and immunorestoration. They will often be quoted in this book. I am particularly grateful to those who have helped me to write it by reviewing some chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I also thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for their willing and efficient co-operation in the preperation of the manuscript. I am finally grateful to all authors of books or articles who authorized me to reproduce their figures or tables. Paris, April 1976 G. MAT~ Contents Chapter 1. Introduction and Definitions 1 Chapter 2. Biological Basis: Tumour Associated Antigens, the Immune Machinery and Its Behaviour Concerning Cancer Cells 5 2. 1. Tumour-Associated Antigens 5 2. 2. The Immune Machinery 19 2. 2. 1. Humoral Mediated Immunity and Cell Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen­ tiation 22 2. 2. 3. T-Lymphocyte Functions 25 2. 2. 4. B-Lymphocyte Functions 30 2. 2. 5. Macrophage Functions 31 2. 2. 6. K-Cell Function 32 2. 3. The Immune Machinery and Cancer Cells 33 2. 3. 1. Mechanisms Involved in Tumour Cell Rejec­ tion 33 2. 3. 1. 1. In vivo Evidence for Tumour Immunity 33 2. 3. 1. 2.

• cancer
• cell
• immunotherapy
• prevention
• therapy
• tumor

• Institut de Cancérologie et d’Immunogénétique, University of Paris Sud, Villejuif, France

  Georges Mathé

• Unité Fred Siguier, Hopital Paul Brousse, Villejuif, France

  Georges Mathé

• Division of Hematology, Institut Gustave Roussy, Villejuif, France

  Georges Mathé

Policies and ethics