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Role of Nitric Oxide in Sepsis and ARDS

  • Book
  • © 1995

Overview

Editors:
  1. M. P. Fink

    1. Department of Surgery, Beth Israel Hospital, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Didier Payen

    1. Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, Paris Cedex 10, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Update in Intensive Care and Emergency Medicine (UICM, volume 24)

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Table of contents (26 chapters)

  1. Front Matter

    Pages I-XIV
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  2. Biochemistry of Nitric Oxide and Regulation of Gene Expression

    1. Front Matter

      Pages 1-1
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    2. Biosynthesis of Nitric Oxide: An Overview

      • B. Mayer
      Pages 3-13

    3. Biochemistry and Synthesis of NO in Sepsis

      • L. L. Shears, T. R. Billiar
      Pages 14-28

    4. Effects of Hypoxia on Inducible Nitric Oxide Synthase (iNOS) in Renal Mesangial Cells

      • E. Michelakis, P. J. Shultz, S. L. Archer
      Pages 29-43

    5. Vascular Smooth Muscle Function under Conditions of Sepsis and Endotoxemia

      • J. R. Parratt, J. C. Stoclet
      Pages 44-61

    6. Nitric Oxide as a Mediator in Gram-Positive Sepsis

      • J. Wilkinson, S. Sriskandan, J. Cohen
      Pages 62-69

  3. Effects of Nitric Oxide on Various Cell Types and Organs

    1. Front Matter

      Pages 71-71
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    2. Nitric Oxide and the Heart in Sepsis

      • A. Kumar, J. E. Parrillo
      Pages 73-99

    3. Influence of Nitric Oxide on Cardiac Systolic and Diastolic Function

      • A. M. Shah
      Pages 100-113

    4. Cellular Actions of Nitric Oxide on the Circulatory System

      • A. M. Lefer
      Pages 114-124

    5. Role of Nitric Oxide in Cerebral Ischemia

      • J. R. Kirsch, R. J. Traystman
      Pages 125-137

    6. Platelet Regulation and Damage in Vascular Thrombotic and Septic Disorders

      • M. W. Radomski, E. Salas
      Pages 138-154

    7. Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis

      • R. L. Danner, J. Cobb, A. L. Van Dervort
      Pages 155-180

    8. Effects of Nitric Oxide on Intestinal Epithelial Structure and Function

      • M. P. Fink, N. Unno, A. L. Salzman
      Pages 181-198

  4. Nitric Oxide in Shock

    1. Front Matter

      Pages 199-199
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    2. Inhibition of Nitric Oxide Synthase Activity in Circulatory Shock: Friend or Foe?

      • C. Thiemermann
      Pages 201-216

    3. Use of Nitric Oxide Synthase Inhibitors to reverse Hyperdynamic Circulation and MOF

      • M. Booke, L. D. Traber, D. L. Traber
      Pages 217-231

    4. Cardiovascular Alterations associated with Interleukin-2 Therapy

      • G. A. Fonseca, R. G. Kilbourn
      Pages 232-252

    5. Blocking the Effects of Nitric Oxide in Septic Shock

      • J. L. Vincent, J. G. Preiser, H. Zhang
      Pages 253-273
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Keywords

About this book

Nitric Oxide (NO) is a free radical, a gas, and a pluripotent product of mammalian cells. Only a few years ago, scientific discussions of NO were largely held in the context of the chemistry of air pollution. Now, however, the great significance of NO as a signalling and cytotoxic molecule has captured the attention of the biomedical community. This book provides a very up-to-date review of the role of NO in sepsis and ARDS. Consideration is given to NO both as a pathophysiologic mediator as well as a therapeutic agent. An internationally recognized group of scientists and clinicians have contributed chapters dealing with cutting-edge science and practical clinical strategies. Numerous tables and charts have been included to aid the reader in understanding this fascinating and important subject.

Editors and Affiliations

  • Department of Surgery, Beth Israel Hospital, Boston, USA

    M. P. Fink

  • Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, Paris Cedex 10, France

    Didier Payen

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