An Antigen Depository of the Immune System: Follicular Dendritic Cells

1. Front Matter

   Pages I-IX

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2. A Theory of Follicular Dendritic Cell Origin

   • A. K. Szakal, Z. F. Kapasi, S. T. Haley, J. G. Tew

   Pages 1-13

3. Follicular Dendritic Cells: Origin and Function

   • E. Heinen, A. Bosseloir, F. Bouzahzah

   Pages 15-47

4. Mechanism of Immune Complex Trapping by Follicular Dendritic Cells

   • T. K. Van den Berg, K. Yoshida, C. D. Dijkstra

   Pages 49-67

5. Follicular Dendritic Cells: Antigen Retention, B Cell Activation, and Cytokine Production

   • M. H. Kosco-Vilbois, D. Scheidegger

   Pages 69-82

6. Role of Follicular Dendritic Cells in the Regulation of B Cell Proliferation

   • A. S. Freedman, D. Wang, J. Scott Phifer, S. N. Manie

   Pages 83-92

7. Murine Follicular Dendritic Cells: Accessory Activities In Vitro

   • J. G. Tew, G. F. Burton, S. Helm, J. Wu, D. Qin, E. Hahn et al.

   Pages 93-104

8. Regulation of Human B Cell Activation by Follicular Dendritic Cell and T Cell Signals

   • G. Grouard, O. de Bouteiller, C. Barthelemy, S. Lebecque, J. Banchereau, Y.-J. Liu

   Pages 105-117

9. Follicular Dendritic Cells: Structure as Related to Function

   • K. Maeda, M. Matsuda, Y. Imai

   Pages 119-139

10. Follicular Dendritic Cells Initiate and Maintain Infection of the Germinal Centers by Human Immunodeficiency Virus

    • K. Tenner-Racz, P. Racz

    Pages 141-159

11. Follicular Dendritic Cells and Infection by Human Immunodeficiency Virus Type 1—A Crucial Target Cell and Virus Reservoir

    • H.-J. Schuurman, P. Joling, D. F. van Wichen, L. H. P. M. Rademakers, R. Broekhuizen, R. A. de Weger et al.

    Pages 161-188

12. Follicular Dendritic Cells in Malignant Lymphomas

    • S. Petrasch

    Pages 189-203

13. Back Matter

    Pages 205-212

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Follicular dendritic cells (FOe) are unique among cells of the immune system. While their morphological characteristics re­ sulted in their inclusion as a 'dendritic cell type', tt1ey differ quite significantly from the other members of the dendritic cell family. In contrast to T-cell-associated dendritic cells or the Langerhans cells found in the skin, FOe reside in highly organized B cell follicles within secondary lymphoid tissues. This site of resi­ dence provided a nomenclature committee in 1982 with the second descriptive factor for the derivation of their name. The cardinal feature of FOe is to trap and retain antigen on the surface of their dendritic processes for extended amounts of time and it is this feature that provides the conceptual compo­ nent for the title of this book. In response to an antigenic challenge, primary B cell follicles undergo dynamic events, giving rise to germinal centers which are associated with activation, expansion, and differentiation processes of B cells. The interactions of B cells with Foe and T cells in the germinal centers are essential for generating the complete repertoire of antibody isotypes obtained during an antibody response. In addition, stimuli either initiated or main­ tained during the germinal center reponse leads to production of high affinity antibodies through the processes of somatic muta­ tion and clonal selection. In this context, FOe act as a pivotal source of antigen. They accumulate foreign proteins (e. g.

• AIDS
• HIV
• T cell
• antibody
• antigen
• cell
• cytokine
• growth
• immune response
• immune system
• immunodeficiency
• infection
• pathology
• tissue
• virus

• Glaxo Institute for Immunology, Plan-les-Ouates Geneva, Switzerland

  Marie H. Kosco-Vilbois

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