Skip to main content
SpringerLink
Log in
Book cover

Apoptosis in Immunology

  • Book
  • © 1995

Overview

Editors:
  1. Guido Kroemer

    1. Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, Villejuif Cedex, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Carlos Martinez-A.

    1. Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, Madrid, Spain

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 200)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. T Cell Apoptosis Triggered via the CD3/T Cell Receptor Complex and Alternative Activation Pathways

    • D. Kabelitz, T. Pohl, K. Pechhold
    Pages 1-14

  3. B Cell Activation and Apoptosis

    • P. Sarthou, L. Benhamou, P.-A. Cazenave
    Pages 15-37

  4. Characterization of Signals Leading to Clonal Expansion or to Cell Death During Lymphocyte B Cell Activation

    • L. Bosca, C. Stauber, S. Hortelano, E. Baixeras, C. Martinez-A.
    Pages 39-50

  5. Glucocorticoid-Induced Death of Immune Cells: Mechanisms of Action

    • J. W. Montague, J. A. Cidlowski
    Pages 51-65

  6. Thymocyte Apoptosis by Glucocorticoids and cAMP

    • M. Jondal, Y. Xue, D. J. McConkey, S. Okret
    Pages 67-79

  7. Regulation of Apoptosis via Steroid Receptors

    • M. Iwata
    Pages 81-94

  8. Calcium and Cyclosporin A in the Regulation of Apoptosis

    • D. J. McConkey, S. Orrenius
    Pages 95-105

  9. Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

    • L. H. Boise, A. R. Gottschalk, J. Quintáns, C. B. Thompson
    Pages 107-121

  10. Lymphocyte Death, p53, and the Problem of the “Undead” Cell

    • D. J. Harrison, S. E. M. Howie, A. H. Wyllie
    Pages 123-135

  11. Death Genes in T Cells

    • J. Woronicz, B. Calnan, A. Winoto
    Pages 137-146

  12. Molecular Events in Thymocyte Apoptosis

    • S. W. Smith, K. A. McLaughlin, B. A. Osborne
    Pages 147-162

  13. Tissue Transglutaminase: A Candidate Effector Element of Physiological Cell Death

    • M. Piacentini
    Pages 163-175

  14. Chronic Activation of the Immune System in HIV Infection: Contribution to T Cell Apoptosis and Vβ Selective T Cell Anergy

    • M. L. Gougeon
    Pages 177-193

  15. Programmed Cell Death and AIDS Pathogenesis: Significance and Potential Mechanisms

    • J. C. Ameisen, J. Estaquier, T. Idziorek, F. De Bels
    Pages 195-211

  16. Programmed Death of T Cells in HIV Infection: Result of Immune Activation?

    • L. Meyaard, F. Miedema
    Pages 213-221

  17. Maintenance of the T Lymphocyte Pool by Inhibition of Apoptosis: A Novel Strategy of Immunostimulation?

    • G. Kroemer, N. Zamzami, P. Marchetti, M. Castedo
    Pages 223-235

  18. Back Matter

    Pages 237-244
    Download chapter PDF
Back to top

Keywords

About this book

In any movement of their life, immune cells, especially T and B lymphocytes, are confronted with an essential choice: to continue their existence or to commit a sort of metabolic suicide that is referred to as apoptosis or programmed cell death. In contrast to most philosophers, lymphocytes and their precursors are constantly susceptible to suicide, and it even appears that the usual cause of T or B cell elimination is suicide rather than death from natural causes, accidents or murder. This book provides a vast overview of lymphocytes suicide: external triggers and internal motives leading to suicidal impulses, accomplices in self-destruction, weapons implicated in self-execution, removal of dead bodies and pharmacological prevention of suicide. Most of the chapters in this book are devoted to the physiology of apoptosis. The goal is to unmask the external triggers of apoptosis, unravel the signal transduction pro­ cesses involved therein and describe the role of oncogenes, "death genes" and effector molecules in the apoptotic cas­ cade. The remaining chapters deal with the pathophysiologi­ cal aspects of lymphocyte apoptosis, namely, as a host contribution to HIV-induced lymphopenia, and therapeutic strategies for the avoidance of lymphocyte death. We are confident that this compendium will contribute to the exploration of cellular suicide, not only from a basic scientist's viewpoint but also with regard to the possible clinical implications of apoptosis (dys)regulation. Far from having a depressing effect on the reader, cellular suicide may thus provide a source of both intellectual excitement and therapeutic inspiration.

Editors and Affiliations

  • Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, Villejuif Cedex, France

    Guido Kroemer

  • Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, Madrid, Spain

    Carlos Martinez-A.

Bibliographic Information

  • Book Title: Apoptosis in Immunology

  • Editors: Guido Kroemer, Carlos Martinez-A.

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-79437-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1995

  • Softcover ISBN: 978-3-642-79439-1Published: 21 December 2011

  • eBook ISBN: 978-3-642-79437-7Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 242

  • Topics: Immunology, Cell Biology, Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation