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Pathways for Cytolysis

  • Book
  • © 1995

Overview

Editors:
  1. Gillian M. Griffiths

    1. Basel Institute of Immunology, Basel, Switzerland

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  2. Jürg Tschopp

    1. Department of Biochemistry, University of Lausanne, Epalinges/Lausanne, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 198)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-IX
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  2. Perforin and Granzymes: Crucial Effector Molecules in Cytolytic T Lymphocyte and Natural Killer Cell-Mediated Cytotoxicity

    • B. Lowin, M. C. Peitsch, J. Tschopp
    Pages 1-24

  3. Fas-Based T Cell-Mediated Cytotoxicity

    • P. Golstein
    Pages 25-37

  4. Structure and Biogenesis of Lytic Granules

    • G. M. Griffiths, Y. Argon
    Pages 39-58

  5. The Role of CD28 Costimulation in the Generation of Cytotoxic T Lymphocytes

    • M. Azuma, L. L. Lanier
    Pages 59-74

  6. Degranulating Cytotoxic Lymphocytes Inflict Multiple Damage Pathways on Target Cells

    • P. A. Henkart, M. S. Williams, H. Nakajima
    Pages 75-93

  7. Granzymes and Apoptosis: Targeting the Cell Cycle

    • A. H. Greenberg, D. W. Litchfield
    Pages 95-119

  8. Perforin, Killer Cells and Gene Transfer Immunotherapy for Cancer

    • E. R. Podack
    Pages 121-130

  9. TIA-1: Structural and Functional Studies on a New Class of Cytolytic Effector Molecule

    • P. Anderson
    Pages 131-143

  10. Calreticulin: A Granule-Protein by Default or Design?

    • R. C. Bleackley, E. A. Atkinson, K. Burns, M. Michalak
    Pages 145-159

  11. A New Function for an Old Enzyme: The Role of DNase I in Apoptosis

    • H. G. Mannherz, M. C. Peitsch, S. Zanotti, R. Paddenberg, B. Polzar
    Pages 161-174

  12. The Ligands and Receptors of the Lymphotoxin System

    • C. F. Ware, T. L. VanArsdale, P. D. Crowe, J. L. Browning
    Pages 175-218

  13. Back Matter

    Pages 219-227
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Keywords

About this book

At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring or generated by gene targeting. It is now clear that there are two predominant pathways which act hand in hand and lead to efficienttarget cell destruction.

Editors and Affiliations

  • Basel Institute of Immunology, Basel, Switzerland

    Gillian M. Griffiths

  • Department of Biochemistry, University of Lausanne, Epalinges/Lausanne, Switzerland

    Jürg Tschopp

Bibliographic Information

  • Book Title: Pathways for Cytolysis

  • Editors: Gillian M. Griffiths, Jürg Tschopp

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-79414-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1995

  • Softcover ISBN: 978-3-642-79416-2Published: 25 December 2011

  • eBook ISBN: 978-3-642-79414-8Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 224

  • Number of Illustrations: 3 illustrations in colour

  • Topics: Immunology, Cell Biology

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