The Pharmacology of Alcohol Abuse

1. Front Matter

   Pages I-XXVI

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2. The Pharmacology of Alcohol Abuse: An Introduction

   • H. R. Kranzler

   Pages 1-10

3. Alcohol-Induced Changes in Neuronal Membranes

   • J. Moring, W. J. Shoemaker

   Pages 11-53

4. Effects of Ethanol on Voltage-Dependent Calcium Channel Function

   • S. W. Leslie

   Pages 55-73

5. Effects of Alcohol on Excitatory Amino Acid Receptor Function

   • P. L. Hoffman

   Pages 75-102

6. Effects of Alcohol on GABA-Mediated Neurotransmission

   • M. K. Ticku, A. K. Mehta

   Pages 103-119

7. Involvement of CNS Catecholamines in Alcohol Self-Administration, Tolerance and Dependence: Preclinical Studies

   • H. H. Samson, P. L. Hoffman

   Pages 121-137

8. 5-HT Mediation of Alcohol Self-Administration, Tolerance and Dependence: Pre-Clinical Studies

   • G. A. Higgins, A. D. Lê, E. M. Sellers

   Pages 139-168

9. Opioid Mediation of Alcohol Self-Administration: Pre-Clinical Studies

   • J. R. Volpicelli, B. J. Berg, N. T. Watson

   Pages 169-184

10. Animal Models of the Alcohol Addiction Process

    • K. A. Grant

    Pages 185-229

11. Ethanol and Neurohormonal Regulation

    • J. Littleton

    Pages 231-260

12. Clinical Application of Findings from Animal Research on Alcohol Self-Administration and Dependence

    • M. K. Romach, D. M. Tomkins

    Pages 261-295

13. Genetic Factors in Alcoholism: Evidence and Implications

    • J. Gelernter

    Pages 297-313

14. Pharmacotherapy and Pathophysiology of Alcohol Withdrawal

    • R. F. Anton, H. C. Becker

    Pages 315-367

15. Drugs to Decrease Alcohol Consumption in Humans: Aversive Agents

    • R. K. Fuller, R. Z. Litten

    Pages 369-381

16. Drugs Attenuating Alcohol Consumption in Humans Through Effects on Various Neurotransmitter Systems

    • C. A. Naranjo, K. E. Bremner

    Pages 383-393

17. Pharmacology of Gastrointestinal Comorbidity in Alcoholics

    • T. M. Worner, P. Manu

    Pages 395-413

18. Drugs for the Treatment of Psychiatric Comorbidity in Alcoholics: Recent Developments

    • M. J. Bohn, D. Hersh

    Pages 415-441

19. Clinical Markers of Alcohol Abuse

    • H. Rommelspacher, C. Müller

    Pages 443-473

20. Interaction of Alcohol With Therapeutic Drugs and Drugs of Abuse

    • B. F. Sands, C. M. Knapp, D. A. Ciraulo

    Pages 475-512

In recent years alcohol abuse has received increased international attention. Such attention is justified by the enormous negative impact that this disorder has on health, as well as on economic and social well-being. Governmental and other sources of research support have promoted substantial investigation into the negative consequences of alcohol, examining both animal models and human subjects. Consequently, there has been a virtual explosion of preclinical and clinical data, much of it focused on alcohol's pharmacologic effects. However, there have been few efforts to integrate this wealth of new information into a single, manageable volume. This volume provides an up-to-date, in-depth treatment of the phar­ macology of alcohol, particularly as it relates to alcohol abuse. The over­ riding theme of the book is the interplay between the preclinical and clinical domains. Increasingly, these areas of investigation have served to inform one another, a trend that can be expected to grow with time. The topics covered include the effects of alcohol on biological systems and the impact of medications on those effects. In addition, recent insights obtained from molecular biological investigations are discussed in terms of their relevance for understanding the effects of alcohol at the cellular level and the implica­ tions of these for the development of medications. Consideration is also given to important methodological issues that influence the evaluation of medications in the context of clinical trials.

• Alcohol Pharmacology
• Alcoholism Treatment
• Alkoholismus
• Etiology of Alcoholism
• Neuropharmacology of Alcohol
• Pharmacotherapy of Alcoholism
• Sucht
• alcoholism
• biology
• ethanol
• molecular biology
• neuropharmacology
• pharmacology
• pharmacotherapy
• research

• Division of Addictive Disorders, Department of Psychiatry, MC2103, University of Connecticut School of Medicine, Farmington, USA

  Henry R. Kranzler

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