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Retroviral Insertion and Oncogene Activation

  • Book
  • © 1991

Overview

Editors:
  1. Hsing-Jien Kung

    1. Dept. of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, USA

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  2. Peter K. Vogt

    1. Dept. of Microbiology, School of Medicine, University of Southern California, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 171)

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Table of contents (5 chapters)

  1. Front Matter

    Pages I-IX
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  2. Retroviral Mutagenesis of Cellular Oncogenes: A Review with Insights into the Mechanisms of Insertional Activation

    • H. J. Kung, C. Boerkoel, T. H. Carter
    Pages 1-25

  3. Mutagenesis of the Mouse Germline Using Retroviruses

    • L. F. Lock, N. A. Jenkins, N. G. Copeland
    Pages 27-41

  4. Insertional Mutagenesis in Mouse Mammary Tumorigenesis

    • R. Nusse
    Pages 43-65

  5. Feline Leukaemia Virus: Generation of Pathogenic and Oncogenic Variants

    • J. C. Neil, R. Fulton, M. Rigby, M. Stewart
    Pages 67-93

  6. Virus-Host Interactions and the Pathogenesis of Murine and Human Oncogenic Retroviruses

    • P. N. Tsichlis, P. A. Lazo
    Pages 95-171

  7. Back Matter

    Pages 173-182
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Keywords

About this book

An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The transcriptional signals in a provirus can activate expression of neighboring cellular genes; the integration even can disrupt and thus inactivate cellular genes. These effects of retroviral genomes take place in cis; they are referred to as insertional mutagenesis and are the subject of this volume. Almost 10 years have passed since W. Hayward, S. Astrin, and their colleagues found that in B cell lymphomas of chickens, induced by avian leukosis virus, transcription of the cellular proto-oncogene myc was upregulated through the integration of a complete or partial provirus in its vicinity. This landmark discovery suggested a mechanism by which retro­ viruses that do not carry cellular oncogenes in their genome ("nonacute retroviruses") can cause cancer. It contributed the first evidence for the carcinogen potential of oncogenes that are not part of a viral genome.

Editors and Affiliations

  • Dept. of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, USA

    Hsing-Jien Kung

  • Dept. of Microbiology, School of Medicine, University of Southern California, Los Angeles, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: Retroviral Insertion and Oncogene Activation

  • Editors: Hsing-Jien Kung, Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-76524-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1991

  • Softcover ISBN: 978-3-642-76526-1Published: 06 December 2011

  • eBook ISBN: 978-3-642-76524-7Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 179

  • Topics: Virology, Cell Biology, Oncology, Cancer Research, Medical Microbiology

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