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Function and Specificity of γ/δ T Cells

International Workshop, Schloß Elmau, Bavaria, FRG October 14–16, 1990

  • Book
  • © 1991

Overview

Editors:
  1. Klaus Pfeffer

    1. Institut für Medizinische, Mirobiologie und Hygiene TU München, München 8, Germany

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  2. Klaus Heeg

    1. Institut für Medizinische, Mirobiologie und Hygiene TU München, München 8, Germany

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  3. Hermann Wagner

    1. Institut für Medizinische, Mirobiologie und Hygiene TU München, München 8, Germany

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  4. Gert Riethmüller

    1. Institut für Immunologie, University of Munich, München, Germany

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 173)

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Table of contents (40 chapters)

  1. Front Matter

    Pages I-XII
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  2. Genomic Organization

    1. Front Matter

      Pages 1-1
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    2. Genetic Organization of the Human T Cell Receptor Gamma Locus

      • Marie-Paule Lefranc, T. H. Rabbitts
      Pages 3-9

  3. Differentiation In Vitro

    1. Front Matter

      Pages 11-11
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    2. Development of Human T Cells Expressing TCR γδ In Vitro

      • V. Groh, M. Fabbi, J. L. Stromminger
      Pages 13-15

  4. Differentiation In Vitro

    1. From the Developmental Expression of γδ T Cell Receptors to the Implications in the Acquisition of Tolerance

      • C. Marinez-A., J. M. Alonso, Alicia Barcena, P. Aparicio, Maria L. Toribio
      Pages 17-23

    2. Culture Conditions Dictate Whether Mouse Fetal Thymus Lobes Generate Predominantly γ/δ or α/βT Cells

      • Cathrin Schleussner, Amanda Fisher, Rhodri Ceredig
      Pages 25-28

    3. Preferential Development of γ/δ- Bearing T Cells in Athymic Nude Bone Marrow

      • R. G. Miller, Patricia Benveniste, J. Reimann
      Pages 29-32

    4. Developmentally Ordered Expression of γδTCR Vδ7 Subfamily Genes

      • S. Wehr, B. Arden
      Pages 33-38

  5. Maturation/Selection

    1. Front Matter

      Pages 39-39
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    2. Tissue Distribution and Repertoire Selection of Human γδT Cells: Comparison With the Murine System

      • J. Borst, Thea M. Vroom, J. D. Bos, J. J. M. Van Dongen
      Pages 41-46

    3. Evidence For Controlled Gene Rearrangements and Cytokine Production During Development of Human TCRγδ+ Lymphocytes

      • H. Spits, H. Yssel, Cathy Brockelhurst, M. Krangel
      Pages 47-55

    4. Thymic and Extrathymic Development of Human γ/δT Cells

      • L. D. McVay, A. C. Hayday, K. Bottomly, S. R. Carding
      Pages 57-63

    5. Differential Effects of Anti-CD3 Antibodies In Vivo and In Vitro on α β and γ δ T Cell Differentiation

      • B. A. Kyewski
      Pages 65-69

    6. The Beginning and the End of the Development of TCRγδ Cells in the Thymus

      • K. Shortman, Li Wu, Katherine A. Kelly, R. Scollay
      Pages 71-80

    7. Cyclosporin A (CsA) Prevents the Generation of Mature Thymic α/βT Cells but Spares γ/δ T Lymphocytes

      • Pia Bader, Sylvia Bendigs, H. Wagner, K. Heeg
      Pages 81-89
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Keywords

About this book

Our current understanding of a/~ T cell receptor (TCR) ex­ pressing T cells advanced from function and specificity to the molecular organization ofthe TCR.We now know that the TCR a and ~ chains together express specificity for (antigenic) peptides presented by the "responder" M H C allele, thus explain­ ing the phenomenon of MHC restriction at a molecular level. Surprisingly even though our perception of the molecular organization of the y5 TCR is well advanced, current knowledge of function and specificity of the y5 T cell subset is poor. There­ fore it appeared rather timely to bring together scientists pioneering research on y5 T cells forthe International Workshop on Function and Specificity ofy5 Tcells,held October11-14, 1990 at Schloss Elmau/Bavaria, FRG. Besides offering a scientific forum for open discussions, it was also hoped that such a workshop would be seminal for collaborative interactions and personal relationships among scientists "addicted" to y 15 T cells.

Editors and Affiliations

  • Institut für Medizinische, Mirobiologie und Hygiene TU München, München 8, Germany

    Klaus Pfeffer, Klaus Heeg, Hermann Wagner

  • Institut für Immunologie, University of Munich, München, Germany

    Gert Riethmüller

Bibliographic Information

  • Book Title: Function and Specificity of γ/δ T Cells

  • Book Subtitle: International Workshop, Schloß Elmau, Bavaria, FRG October 14–16, 1990

  • Editors: Klaus Pfeffer, Klaus Heeg, Hermann Wagner, Gert Riethmüller

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-76492-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1991

  • Softcover ISBN: 978-3-642-76494-3Published: 22 November 2011

  • eBook ISBN: 978-3-642-76492-9Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 296

  • Topics: Medical Microbiology, Allergology, Immunology, Cell Biology

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