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The Third Component of Complement

Chemistry and Biology

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. John D. Lambris

    1. Basel Institute for Immunology, Basel, Switzerland

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 153)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-IX
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  2. Participation of C3 and its Ligands in Complement Activation

    • J. E. Volanakis
    Pages 1-21

  3. Biosynthesis and Genetics of C3

    • S. R. Barnum, G. Fey, B. F. Tack
    Pages 23-43

  4. Molecular Aspects of C3 Interactions and Structural/Functional Analysis of C3 from Different Species

    • J. D. Becherer, J. Alsenz, J. D. Lambris
    Pages 45-72

  5. The Thioester Bond of C3

    • R. P. Levine, A. W. Dodds
    Pages 73-82

  6. Complement Receptor Type 1 (C3b/C4b Receptor; CD35) and Complement Receptor Type 2 (C3d/Epstein-Barr Virus Receptor; CD21)

    • D. T. Fearon, J. M. Ahearn
    Pages 83-98

  7. The Leukocyte Cell Surface Receptor(s) for the iC3b Product of Complement

    • H. Rosen, S. K. Alex Law
    Pages 99-122

  8. Decay-Accelerating Factor and Membrane Cofactor Protein

    • D. M. Lublin, J. P. Atkinson
    Pages 123-145

  9. Factor H

    • D. P. Vik, P. MuñOz-Cánoves, D. D. Chaplin, B. F. Tack
    Pages 147-162

  10. C3 Binding Proteins of Foreign Origin

    • M. P. Dierich, H. P. Huemer, W. M. Prodinger
    Pages 163-180

  11. Structure and Function of C3a Anaphylatoxin*

    • T. E. Hugli
    Pages 181-208

  12. Molecular Modelling of C3 and its Ligands

    • R. B. Sim, S. J. Perkins
    Pages 209-222

  13. C3 Deficiencies

    • D. Bitter-Suermann, R. Burger
    Pages 223-233

  14. Structural and Functional Analysis of C3 Using Monoclonal Antibodies

    • J. Alsenz, J. D. Becherer, B. Nilsson, J. D. Lambris
    Pages 235-248

  15. Back Matter

    Pages 249-251
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Keywords

About this book

The third component of complement, C3, is one of the most versatile proteins and an important participant in immune surveillance and immune response pathways. Its multifunctio­ nality is based on its ability to interact specifically with multiple serum complement proteins, cell surface receptors, and mem­ brant;-associated regulatory proteins. One of its most intriguing strategies of interaction with cell surfaces is the covalent binding of activated C3 through the internal thioester. The field has expanded over the past 10 years and a wealth of information has accumulated. C3 from various species and many of the human C3 binding proteins have been cloned and expressed. Numerous cellular responses mediated by the diffe­ rent fragments of C3 have been described. The findings that C3 interacts in a ligand-receptor-like fashion with proteins of nonself origin such as the gC of herpes simplex virus, a 70-kDa protein from Candida albicans, proteins from Epstein-Barr virus, etc. has opened a new field of investigation. The papers assembled in this volume summarize the wealth of data on the various aspects of the C3 interactions; together they bring to the reader new information on the chemistry, molecular gene­ tics, biology, and pathophysiology of C3 and C3-binding proteins. Emphasis is given to structural features as they relate to functions. Spring 1989 JOHN D. LAMBRIS, HANS J. MULLER-EBERHARD Table of Contents J. E. VOLANAKIS: Participation of C3 and Its Ligands in Complement Activation . . . . . . . . . . . 1 S. R. BARNUM, G. FEY, and B. F. TACK: Biosynthesis and Genetics of C3 . . . . . . . . . . . . .

Editors and Affiliations

  • Basel Institute for Immunology, Basel, Switzerland

    John D. Lambris

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