Transforming Proteins of DNA Tumor Viruses

1. Front Matter

   Pages I-XIV

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2. The Transforming Protein of Simian Virus 40: Large T Antigen and Its Interaction with the Cellular Protein p 53

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction

      • Rolf Knippers, Arnold J. Levine

      Pages 3-7

   3. Structure and Function of SV40 Large T Antigen Communication Between Functional Domains

      • E. Fanning, J. Schneider, A. Arthur, A. Höss, I. Moarefi, S. Modrow

      Pages 9-19

   4. A Genetic Analysis of the Zinc Finger of SV40 Large T Antigen

      • G. Loeber, R. Parsons, P. Tegtmeyer

      Pages 21-29

   5. Effects of Amino Acid Phosphorylation on the DNA Binding Properties of Large T Antigen

      • K. Klausing, R. Knippers

      Pages 31-35

   6. SV40 T Antigen Catalyzed Duplex DNA Unwinding

      • M. Scheffner, R. Wessel, H. Stahl

      Pages 37-45

   7. Control of Transcription in Vitro from Simian Virus 40 Promoters by Proteins from Viral Minichromosomes

      • P. Beard, H. Bruggmann

      Pages 47-54

   8. Dissection of the T Antigen/Mouse p53 Complex and Its Inhibitory Effects on Viral Origin-Directed DNA Replication in Vivo and in Vitro

      • H.-W. Stürzbecher, K. Rudge, R. Brain, C. Addison, M. Grimaldi, J. R. Jenkins

      Pages 55-62

   9. Interactions Between SV40 and Cellular Oncogenes in the Transformation of Primary Rat Cells

      • D. Michalovitz, A. Amsterdam, M. Oren

      Pages 63-75

   10. Metabolic Stabilization of p53 in SV40-Transformed Cells Correlates with Expression of the Transformed Phenotype but is Independent from Complex Formation with SV40 Large T Antigen

       • W. Deppert, T. Steinmayer

       Pages 77-83

   11. SV40 Large T Antigen Induces a Protein Kinase Responsible for Phosphorylation of the Cellular Protein p53

       • K. H. Scheidtmann

       Pages 85-88

   12. Evidence for Threshold Effects in Transformation of Pancreatic β Cells by SV40 T Antigen in Transgenic Mice

       • S. Efrat, D. Hanahan

       Pages 89-95

   13. The Biological Activity of Early SV40 Antisense RNA and DNA Molecules

       • M. Graessmann, A. Graessmann

       Pages 97-103

3. Polyoma Virus Middle T Antigen

   1. Front Matter

      Pages 105-105

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   2. Introduction

      • Rolf Knippers, Arnold J. Levine

      Pages 107-108

   3. Mechanism of Activation of Complexed pp60^c-src by the Middle T Antigen of Polyomavirus

      • S. H. Cheng, R. Harvey, H. Piwnica-Worms, P. C. Espino, T. M. Roberts, A. E. Smith

      Pages 109-120

   4. Further Characterisation of the Complex Containing Middle T Antigen and pp60

      • S. A. Courtneidge

      Pages 121-128

   5. The Mutagenic and Immortalizing Potential of Polyoma virus Large T Antigen

      • M. Strauss, L. Lübbe, U. Kiessling, M. Platzer, B. E. Griffin

      Pages 129-134

4. Transforming Functions of Papillomaviruses

   1. Front Matter

      Pages 135-135

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It is surprising, and even disappointing, that there have been very few meetings and published volumes resulting from these meetings that focus attention upon all of the groups of DNA tumor viruses. Historically, separate meetings were held each year for the adenovirus-SV40-polyoma researchers, the herpes­ viruses, hepatitis B virus and the papillomaviruses. It was as if these four virus groups were four fields of study developing independently with a literature and culture of their own. When a virologist crossed the field from the adenovirus group to the herpesvirus or papillomaviruses, he or she was lost to their former group because of the structure of separate meetings and remote literature. This, of course, has resulted from historical accident and is being rectified by the rapid progress made in our understanding of how these viruses contribute to the causation of cancer in animals and humans. It was pre­ cisely because of these factors that it was time to hold a meeting and publish its proceedings on the subject of transforming proteins of DNA tumor viruses. For the first time, DNA tumor viruses were defined as all of the virus groups that can contribute to cancer in animals with the exception, unfortunately, of the . poxviruses. The purpose of the meeting was to bring together scientists who rarely attend meetings together but actually work on the same problems with different viruses.

• DNA
• RNA
• antigen
• cancer
• gene
• hepatitis
• hepatitis B
• liver
• molecular biology
• protein
• proteins
• tumor
• tumorigenesis
• virology
• virus

• Fakultät für Biologie, Universität Konstanz, Konstanz, Germany

  Rolf Knippers

• Department of Biology, Princeton University, Princeton, USA

  Arnold J. Levine

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