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Pharmacology of the Skin II

Methods, Absorption, Metabolism and Toxicity, Drugs and Diseases

  • Book
  • © 1989

Overview

Editors:
  1. Malcolm W. Greaves

    1. The Institute of Dermatology, St. Thomas’s Hospital, London, Great Britain

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    You can also search for this editor in PubMed   Google Scholar

  2. Sam Shuster

    1. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, Newcastle upon Tyne, Great Britain

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 87 / 2)

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Table of contents (42 chapters)

  1. Front Matter

    Pages I-XXXVII
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  2. Methods

    1. Front Matter

      Pages 1-1
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    2. Methods for the Study of Proliferative Rates in Epidermis

      • R. Dover, N. A. Wright
      Pages 3-11

    3. Tissue and Fluids: Sampling Techniques

      • R. Marks
      Pages 13-17

    4. Measurement of Sweating and Sweat Gland Function

      • K. J. Collins
      Pages 19-22

    5. Measurement of Human Sebaceous Gland Function

      • W. J. Cunliffe
      Pages 23-26

    6. Methods for Assessing the Effect of Drugs on Hair and Nails

      • R. P. R. Dawber, N. B. Simpson
      Pages 27-31

    7. Measurement of Drug Action in the Skin: Sensation

      • B. Lynn
      Pages 33-49

    8. The Measurement of Itch

      • S. Shuster
      Pages 51-54

    9. Measurement of Skin Thickness, Wealing, Irritant, Immune and Ultraviolet Inflammatory Response in Skin

      • P. M. Farr, C. M. Lawrence, S. Shuster
      Pages 55-62

    10. Measurement of Drug Action in Skin: Dermal Connective Tissue

      • B. Nusgens, C. M. Lapière
      Pages 63-76

    11. Microbiological Sampling Techniques

      • K. T. Holland
      Pages 77-79

    12. Clinical Trial Methods

      • M. Corbett, A. Herxheimer
      Pages 81-90

  3. Absorption, Metabolism and Toxicity

    1. Front Matter

      Pages 91-91
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    2. The Properties of Skin as a Diffusion Barrier and Route for Absorption

      • R. C. Scott, P. H. Dugard
      Pages 93-114

    3. Skin as a Mode for Systemic Drug Administration

      • J. E. Shaw, S. K. Chandrasekaran
      Pages 115-122

    4. Drug Metabolism in the Skin

      • H. Kappus
      Pages 123-163

    5. Skin Cancer (Excluding Melanomas)

      • F. Marks
      Pages 165-194

    6. Toxicology of Cosmetics

      • J. D. Middleton
      Pages 195-207

    7. Drug Sensitisation

      • J. R. Gibson
      Pages 209-224
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Keywords

About this book

The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un­ resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.

Editors and Affiliations

  • The Institute of Dermatology, St. Thomas’s Hospital, London, Great Britain

    Malcolm W. Greaves

  • Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, Newcastle upon Tyne, Great Britain

    Sam Shuster

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