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Mechanisms in B-Cell Neoplasia 1988

Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 23–25, 1988

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Michael Potter

    1. Laboratory of Genetics National Institutes of Health, National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Fritz Melchers

    1. Basel Institute for Immunology, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 141)

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Table of contents (45 papers)

  1. Front Matter

    Pages I-XIV
    Download chapter PDF

  2. Pathogenetic Mechanisms

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Early B Cell Tumors

      1. B Cell Precursors in Bone Marrow: In Vivo Proliferation, Localization, Stimulation by Activated Macrophages and Implications for Oncogenesis
        • D. G. Osmond, Y.-H. Park, K. Jacobsen
        Pages 2-10
      2. Lymphoid-Restricted Stem Cells
        • R. A. Phillips, D.-D. Wu, G. M. Fulop
        Pages 11-15
      3. Recombinant Interleukin-7 Supports the Growth of Normal B Lymphocyte Precursors
        • G. Lee, A. E. Namen, S. Gillis, P. W. Kincade
        Pages 16-18
      4. Mac-1+ Bone Marrow Cells Include Precursors of B Cells and T Cells
        • K. L. Holmes, J. S. Lee, H. C. Morse III
        Pages 19-26
      5. Molecular Characterization of a Transforming Retrovirus Involved in Pre-B Cell Lymphomas
        • W. Y. Langdon, J. W. Hartley, S. P. Klinken, S. K. Ruscetti, H. C. Morse III
        Pages 27-30
      6. In Vitro Transformation of Murine Bone Marrow Cells with a v-<i>raf</i>/v-<i>myc</i> Retrovirus Yields Clonally Related Mature B Cells and Macrophages
        • M. Principato, S. P. Klinken, J. L. Cleveland, U. R. Rapp, K. L. Holmes, J. H. Pierce et al.
        Pages 31-41
      7. Closely Related BCR/ABL Oncogenes Are Associated with the Distinctive Clinical Biologies of Philadelphia Chromosome Positive Chronic Myelogenous and Acute Lymphocytic Leukemia
        • O. N. Witte
        Pages 42-49
      8. The Pathogenesis of Tumors Induced by Helper Virus-Free Abelson Murine Leukemia Virus
        • P. L. Green, D. Kaehler, R. Risser
        Pages 50-57
      9. The Development of Three Distinct Avian B Cell Lymphomas
        • E. H. Humphries, C. Frisch Barth, E. Pizer
        Pages 58-66
      10. Bursal Stem Cells as Targets for <i>myc</i>-Induced Preneoplastic Proliferation and Maturation Arrest
        • P. E. Neiman, E. B. Gehly, L. M. Carlson, R. C. Cotter, C. B. Thompson
        Pages 67-74
      11. Molecular Analysis of an AIDS-Associated Burkitt’s Lymphoma: Near-Identity with Endemic Cases
        • F. G. Haluska, G. Russo, M. Andreeff, C. M. Croce
        Pages 75-79

    3. B Cell and Plasma Cell Tumors

      1. Transgenic Mouse Models for Hematopoietic Tumorigenesis
        • A. W. Harris, W. Y. Langdon, W. S. Alexander, I. K. Hariharan, H. Rosenbaum, D. Vaux et al.
        Pages 82-93
      2. Genetic Studies on Eµ-<i>myc</i> Transgenic Mice
        • C. L. Sidman, J. D. Marshall, A. W. Harris
        Pages 94-99
      3. Differential Expression of <i>myc</i>-family Genes During Development: Normal and Deregulated N-<i>myc</i> Expression in Transgenic Mice
        • R. Dildrop, K. Zimmerman, R. A. DePinho, G. D. Yancopoulos, A. Tesfaye, F. W. Alt
        Pages 100-109
      4. Plasmacytoma Induction by J Series of v-<i>myc</i> Recombinant Retroviruses: Evidence for the Requirement of Two (<i>raf</i> and <i>myc</i>) Oncogenes for Transformation
        • J. Troppmair, M. Huleihel, J. Cleveland, J. F. Mushinski, J. Kurie, H. C. Morse III et al.
        Pages 110-114
      5. Synergy of an IgH Promoter-Enhancer-Driven c-<i>myc</i>/v-Ha-<i>ras</i> Retrovirus and Pristane in the Induction of Murine Plasmacytomas
        • R. Clynes, L. W. Stanton, J. Wax, S. Smith-Gill, M. Potter, K. B. Marcu
        Pages 115-124
      6. The Genetics of Susceptibility to RIM-Induced Plasmacytomagenesis
        • B. Mock, J. Wax, R. Clynes, K. B. Marcu, M. Potter
        Pages 125-127
      7. Significance of Chromosome 8 Breakpoint Location in Burkitt’s Lymphoma: Correlation with Geographical Origin and Association with Epstein-Barr Virus
        • F. Barriga, J. Kiwanuka, M. Alvarez-Mon, B. Shiramizu, B. Huber, P. Levine et al.
        Pages 128-137
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Keywords

About this book

The papers in this book were presented at the 6th Workshop on Mechanisms in B-Cell Neoplasia, held in Bethesda, March 23-25, 1988. On alternate years this meeting is sponsored by the . ;. Basel Institute of Immunology in Basel, Switzerland and by the National Cancer Institute in Bethesda, and is attended by 100 to 150 parti­ cipants. This 6th workshop, like the preceding five, was characterized by intense and enthusiastic discussion which reflects, we think, the exciting growth and development of this field. It is quite clear, however, that despite many general advances an understanding of the precise underlying mechanisms in B-cell tumor development is not yet defined. Probably, there is no single mechanism for all the various forms of B-cell neo­ plastic development. Many different forms of B-cell neoplasms are known, and these are distinguished by several characteristics: 1) the stage of development attained by the tumor stem cells; 2) mode of growth (slow or fast); 3) association with natural or inductive etiologic agents and 4) specific and consistent mutational mechanisms such as retroviral insertion, chromosomal rearrangement. Those charac­ teristic forms which arise naturally in relatively high frequency or those tumors with hallmark properties which can be induced consistently are the models most frequently studied, e. g. , endemic Burkitt's lymphoma, follicular lymphoma, acute and chronic lymphocytic leukemia and mUltiple myeloma in man; bursal lymphoma in chickens; Abelson virus induced pre B cell lymphomas and plasmacytomas in mice and immunocytomas in rats. Each model system, has special problems and advantages.

Editors and Affiliations

  • Laboratory of Genetics National Institutes of Health, National Cancer Institute, Bethesda, USA

    Michael Potter

  • Basel Institute for Immunology, Basel, Switzerland

    Fritz Melchers

Bibliographic Information

  • Book Title: Mechanisms in B-Cell Neoplasia 1988

  • Book Subtitle: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 23–25, 1988

  • Editors: Michael Potter, Fritz Melchers

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-74006-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1988

  • Softcover ISBN: 978-3-642-74008-4Published: 08 December 2011

  • eBook ISBN: 978-3-642-74006-0Published: 07 March 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIV, 340

  • Topics: Allergology, Immunology, Oncology, Biochemistry, general, Cancer Research

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