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New Neuromuscular Blocking Agents

Basic and Applied Aspects

  • Book
  • © 1986

Overview

Editors:
  1. Dimitry A. Kharkevich

    1. Department of Pharmacology, Academy of Medical Sciences First Medical Institute, Moscow, USSR

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 79)

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Table of contents (33 chapters)

  1. Front Matter

    Pages I-XXIV
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  2. Neuromuscular Blocking Agents: General Considerations

    1. Neuromuscular Blocking Agents: General Considerations

      • D. A. Kharkevich
      Pages 1-16

  3. The End-Plate Acetylcholine Receptors: Structure and Function

    1. The End-Plate Acetylcholine Receptors: Structure and Function

      • L. P. Wennogle
      Pages 17-56

  4. Pharmacodynamics and Pharmacokinetics of Neuromuscular Blocking Agents

    1. Front Matter

      Pages 57-57
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    2. On the Principles of Postsynaptic Action of Neuromuscular Blocking Agents

      • D. Colquhoun
      Pages 59-113

    3. On the Hydrophobic Interaction of Neuromuscular Blocking Agents with Acetylcholine Receptors of Skeletal Muscles

      • D. A. Kharkevich, A. P. Skoldinov
      Pages 115-139

    4. Prejunctional Actions of Cholinoceptor Agonists and Antagonists, and of Anticholinesterase Drugs

      • W. C. Bowman, A. J. Gibb, A. L. Harvey, I. G. Marshall
      Pages 141-170

    5. On the Comparative Sensitivity of Acetylcholine Receptors of Various Groups of Skeletal Muscles to Neuromuscular Blocking Agents

      • D. A. Kharkevich, V. P. Fisenko
      Pages 171-189

    6. Antimuscarinic and Ganglion-Blocking Activity of Neuromuscular Blocking Agents

      • D. A. Kharkevich, V. A. Shorr
      Pages 191-224

    7. The Interaction of Neuromuscular Blocking Agents With Human Cholinesterases and Their Binding to Plasma Proteins

      • F. F. Foldes, A. Deery
      Pages 225-231

    8. On the Effect of Neuromuscular Blocking Agents on the Central Nervous System

      • D. A. Kharkevich
      Pages 233-262

    9. Biodegradation and Elimination of Neuromuscular Blocking Agents

      • J. B. Stenlake
      Pages 263-276

  5. On the Relationship Between the Chemical Structure and the Neuromuscular Blocking Activity

    1. Front Matter

      Pages 277-277
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    2. Methods for the Experimental Evaluation of Neuromuscular Blocking Agents

      • D. A. Kharkevich
      Pages 279-299

    3. Steroid Derivatives

      • M. Riesz, E. Kárpáti, L. Szporny
      Pages 301-322

    4. The Derivatives of Carboxylic Acids

      • D. A. Kharkevich, A. P. Skoldinov
      Pages 323-369

    5. Quinuclidinium Compounds

      • M. D. Mashkovsky, L. N. Yakhontov, V. V. Churyukanov
      Pages 371-382

    6. Derivatives of Terphenyl

      • N. V. Khromov-Borisov
      Pages 383-390

    7. Delphinium Alkaloids

      • M. D. Mashkovsky, V. V. Churyukanov
      Pages 391-397

  6. Preclinical Pharmacology of New Neuromuscular Blocking Drugs

    1. Front Matter

      Pages 399-399
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Keywords

About this book

The problems associated with the pharmacologic and physiologic regulation of neuromuscular transmission and of the morphofunctional organization of neuromuscular junctions have attracted a wide range of investigators. Numerous handbooks, monographs, and reviews are devoted to this subject. At the same time, many fundamental and applied aspects of this trend continue to progress succesfully. In recent years, new experimental and clinical data on the structure and function of neuromuscular junctions have been gained, and new, more perfect neuromuscular blocking agents have been designed. It is these data that the present handbook mainly deals with. A considerable number of chapters have been written by authors from eastern Europe. This was done intentionally since much of their work has previously been published only in their own languages, and is thus inaccessible to most Western readers. This is why some of the data included in the volume are not quite the latest, but they contain fruitful ideas or important results and are of value for further progress in the pharmacology of neuromuscular transmission. Naturally, the methodological level of the investigations differs, depending on when they were carried out. The handbook contains a number of selected chapters on the pharmacology of neuromuscular junctions; they comprise data otherwise insufficiently reviewed or not dealt with at all. They furthermore reflect the up-to-date state of the problem and probable directions of further developments in this field. D. A. KHARKEVICH Contents CHAPTER 1 Neuromuscular Blocking Agents: General Considerations D. A. KHARKEVICH . . . . . . . . . . . . . . . .

Editors and Affiliations

  • Department of Pharmacology, Academy of Medical Sciences First Medical Institute, Moscow, USSR

    Dimitry A. Kharkevich

Bibliographic Information

  • Book Title: New Neuromuscular Blocking Agents

  • Book Subtitle: Basic and Applied Aspects

  • Editors: Dimitry A. Kharkevich

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-70682-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-642-70684-4Published: 13 December 2011

  • eBook ISBN: 978-3-642-70682-0Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXIV, 744

  • Topics: Pharmacology/Toxicology, Pharmacy

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