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Cyclic Nucleotides

Part II: Physiology and Pharmacology

  • Book
  • © 1982

Overview

Editors:
  1. John W. Kebabian

    1. Biochemical Neuropharmacology Unit, National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. James A. Nathanson

    1. Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 58 / 2)

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Table of contents (22 chapters)

  1. Front Matter

    Pages I-XXX
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  2. Physiology and Pharmacology of Cellular Regulatory Processes

    1. Front Matter

      Pages 1-1
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    2. Regulation of Carbohydrate Metabolism by Cyclic Nucleotides

      • J. H. Exton
      Pages 3-87

    3. Regulation of Lipid Metabolism by Cyclic Nucleotides

      • J. N. Fain
      Pages 89-150

    4. Regulation of the Cell Cycle and Cellular Proliferation by Cyclic Nucleotides

      • D. L. Friedman
      Pages 151-188

    5. Regulation of Development by Cyclic Nucleotides and Inorganic Ions

      • D. McMahon
      Pages 189-225

    6. Regulation of Cell Secretion: The Integrated Action of Cyclic AMP and Calcium

      • M. J. Berridge
      Pages 227-270

    7. Regulation of Water and Electrolyte Movement by Vasopressin and Cyclic Nucleotides in Kidney

      • D. A. Ausiello, J. Orloff
      Pages 271-303

    8. Regulation of Cellular Excitability by Cyclic Nucleotides

      • G. R. Siggins
      Pages 305-346

    9. Regulation of Cardiac Contractile Activity by Cyclic Nucleotides

      • A. M. Katz
      Pages 347-364

    10. Cyclic Nucleotides as First Messengers

      • R. van Driel
      Pages 365-386

  3. Physiology and Pharmacology of Organ Systems

    1. Front Matter

      Pages 387-387
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    2. The Role of Cyclic Nucleotides in the Nervous System

      • T. V. Dunwiddie, B. J. Hoffer
      Pages 389-463

    3. The Role of Cyclic Nucleotide Metabolism in the Eye

      • D. B. Farber
      Pages 465-524

    4. The Role of Cyclic Nucleotides in the Control of Anterior Pituitary Gland Activity

      • F. Labrie, P. Borgeat, J. Drouin, L. Lagace, V. Giguere, V. Raymond et al.
      Pages 525-566

    5. The Role of Cyclic Nucleotides in the Thyroid Gland

      • S. D. Holmes, J. B. Field
      Pages 567-597

    6. Parathyroid Hormone, Bone and Cyclic AMP

      • P. Barrett, H. Rasmussen
      Pages 599-622

    7. The Role of Cyclic Nucleotides and Calcium in Adrenocortical Function

      • B. L. Brown
      Pages 623-650

    8. A Role of Cyclic AMP in the Gastrointestinal Tract: Receptor Control of Hydrogen Ion Secretion by Mammalian Gastric Mucosa

      • W. J. Thompson, E. D. Jacobson, G. C. Rosenfeld
      Pages 651-682

    9. The Role of Cyclic Nucleotides in the Vasculature

      • D. H. Namm
      Pages 683-690
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Keywords

About this book

Cyclic nucleotides are intimately involved in the consequences of either stimulation or blockade of receptors; therefore, an understanding of the biochemistry of cyclic nucleotides ought to be important for pharmacologists. Pharmacology is a science that among other things investigates chemical compounds that affect the physiology of cells, tissues and organs. Frequently pharmacologists account for the effect of low concentrations of a drug upon a tissue by invoking the presence of a receptor upon the surface of the cell. Traditional pharmacologists excelled at identifying and classifying the properties of receptors. A. J. CLARK'S monograph in the earlier series of the Handbook of Experimental Pharmacology (CLARK 1937) summarized the mathematics underlying the traditional pharmacological approach towards receptors. By its nature, however, classic pharmacology provided little useful information about the intracellular events occurring as a consequence of occupying a receptor; for example, ALQUIST (1948) identified the beta-adrenocep­ tor, but he did not provide any insight into how stimulation of the receptor produces tissue-specific physiological responses. The discovery of cyclic AMP by RALL and SUTHERLAND (see RALL, Vol. I) led to biochemical investigations of many different receptors (including ALQUIST'S beta-adrenoceptor) that share a cyclic nucleotide as a common factor in the biochemical mechanisms that translate the occupancy of receptors into physiological effects. Ten years ago, in the introduction to their monograph on cyclic nucleotides, ROBISON et al. (1971) commented on the rapid growth of interest in cyclic nucleotides over the preceding years.

Editors and Affiliations

  • Biochemical Neuropharmacology Unit, National Institutes of Health, Bethesda, USA

    John W. Kebabian

  • Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Boston, USA

    James A. Nathanson

Bibliographic Information

  • Book Title: Cyclic Nucleotides

  • Book Subtitle: Part II: Physiology and Pharmacology

  • Editors: John W. Kebabian, James A. Nathanson

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-68393-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1982

  • Softcover ISBN: 978-3-642-68395-4Published: 22 December 2011

  • eBook ISBN: 978-3-642-68393-0Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXX, 888

  • Topics: Pharmacology/Toxicology, Pharmacy

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