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Natural Resistance to Tumors and Viruses

  • Book
  • © 1981

Overview

Editors:
  1. Otto Haller

    1. Institut für Immunologie und Virologie, Universität Zürich, Zürich, Switzerland

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 92)

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Table of contents (7 chapters)

  1. Front Matter

    Pages I-VI
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  2. Genetically Controlled Resistance to Flavivirus and Lactate-Dehydrogenase-Elevating Virus-Induced Disease

    • Margo A. Brinton
    Pages 1-14

  3. Resistance to Herpes Simplex Virus — Type 1 (HSV-1)

    • C. Lopez
    Pages 15-24

  4. Inborn Resistance of Mice to Orthomyxoviruses

    • Otto Haller
    Pages 25-52

  5. Role of Macrophages and Interferon in Natural Resistance to Mouse Hepatitis Virus Infection

    • Jean-Louis Virelizier
    Pages 53-64

  6. Genetic Resistance to Friend Virus-Induced Erythroleukemia and Immunosuppression

    • Vinay Kumar, Michael Bennett
    Pages 65-82

  7. Natural Cell-Mediated Immunity During Viral Infections

    • Raymond M. Welsh
    Pages 83-106

  8. Surveillance of Primitive Cells by Natural Killer Cells

    • Rolf Kiessling, Hans Wigzell
    Pages 107-123

  9. Back Matter

    Pages 125-130
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Keywords

About this book

Natural resistance is now coming to be recognized as a potentially important phenomenon in host defense against infection and ma­ lignancy. Genetically controlled resistance mechanisms are usUally effective early in infection and before conventional immune responses are generated. Comparisons of experimental systems where natural resistance plays a prominent role demon­ strate the complexities of the host defense mechanisms involved, as evidenced in the present volume. Nevertheless, some com­ mon components of genetic resistance are discernible and largely comprise natural killer cells, macrophages, and interferon These and additional factors would seem to constitute a first line of de­ fense in host resistance against both viruses and tumors. It is evi­ dent that considerable variation in the relative importance of di­ stinct mechanisms may be found among various resistance sy­ stems and that, most likely, additional effector functions will be discovered. Resistance to tumors and most viruses is under polygenic control, has a complex mode of inheritance, and depends on appro­ priately complex effector mechanisms. Instances, however, whe­ re a single gene locus determines resistance or susceptibility to a virus, as in the case of resistance to flaviviruses or influenza viru­ ses, would seem to offer good prospects for elucidating the basic factors involved. Resistance to influenza virus would indeed seem to represent a comparatively simple situation: resistance is expressed at the host cell level, and interferon is its main media­ tor. The present volume provides insight into current concepts of such resistance mechanisms.

Editors and Affiliations

  • Institut für Immunologie und Virologie, Universität Zürich, Zürich, Switzerland

    Otto Haller

Bibliographic Information

  • Book Title: Natural Resistance to Tumors and Viruses

  • Editors: Otto Haller

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-68069-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1981

  • Softcover ISBN: 978-3-642-68071-7Published: 09 January 2012

  • eBook ISBN: 978-3-642-68069-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VI, 130

  • Topics: Medical Microbiology, Allergology, Immunology

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