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Antipsychotics

  • Book
  • © 1996

Overview

Editors:
  1. John G. Csernansky

    1. Department of Psychiatry, Washington University, School of Medicine, St. Louis, USA

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 120)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XXV
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  2. Classification Schemes for Antipsychotic Drugs

    • Susan A. Minchin, John G. Csernansky
    Pages 1-27

  3. Molecular Models and Structure — Activity Relationships

    • Svein G. Dahl
    Pages 29-41

  4. Interaction of Antipsychotic Drugs with Dopamine Receptor Subtypes

    • Deborah Hartman, Frederick Monsma, Olivier Civelli
    Pages 43-75

  5. Atypical Antipsychotic Drugs: Clinical and Preclinical Studies

    • S. Hossein Fatemi, Herbert Y. Meltzer, Bryan L. Roth
    Pages 77-115

  6. Sites and Mechanisms of Action of Antipsychotic Drugs as Revealed by Immediate-Early Gene Expression

    • Ariel Y. Deutch
    Pages 117-161

  7. Basic Neurophysiology of Antipsychotic Drug Action

    • Patricio O‚Donnell, Anthony A. Grace
    Pages 163-202

  8. Tolerance and Sensitization to the Effects of Antipsychotic Drugs on Dopamine Transmission

    • Ronald E. See, Peter W. Kalivas
    Pages 203-224

  9. The Behavioural Pharmacology of Typical and Atypical Antipsychotic Drugs

    • Sven Ove Ögren
    Pages 225-266

  10. Antipsychotic Drug Action After Lesions to the Hippocampus or Frontal Cortex

    • Mark E. Bardgett, John G. Csernansky
    Pages 267-288

  11. An Animal Model of Sensorimotor Gating Deficits in Schizophrenia Predicts Antipsychotic Drug Action

    • N. R. Swerdlow, D. L. Braff, V. P. Bakshi, M. A. Geyer
    Pages 289-312

  12. Patterns of Clinical Efficacy for Antipsychotic Drugs

    • Julia Golier, Michael Davidson
    Pages 313-331

  13. Efficacy of Novel Antipsychotic Drugs in Treatment-Refractory Schizophrenia

    • Herbert Y. Meltzer, Rakesh Ranjan
    Pages 333-357

  14. Antipsychotic-Induced Side Effects Related to Receptor Affinity

    • Linda Peacock, Jes Gerlach
    Pages 359-388

  15. Biological Predictors of Antipsychotic Treatment Response

    • Amy R. Koreen, Brian Sheitman, Jeffrey Lieberman
    Pages 389-444

  16. Effects of Antipsychotic Drugs on Neuropsychological Measures

    • William O. Faustman, Anne L. Hoff
    Pages 445-477

  17. Antipsychotic Drugs in Children and Adolescents

    • Edward S. Brodkin, Christopher J. McDougle, James F. Leckman
    Pages 479-504

  18. Use of Antipsychotic Drugs in the Elderly

    • Bruce G. Pollock, Benoit H. Mulsant
    Pages 505-529

  19. Back Matter

    Pages 531-541
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Keywords

About this book

Antipsychotic drugs were first discovered in 1953, and not since the late 1970s has the Handbook of Experimental Pharmacology taken up this topic. A new treatment of this topic would be due under any circumstances; however, this is now particularly true, since remarkable progress has been made on several fronts in furthering our understanding of the mechanisms of antipsychotic drug action. First, we have learned that schizophrenia is an illness with particu­ lar neuroanatomical abnormalities, many of which suggest that the illness is caused by errors in neurodevelopment. These findings have helped to form a context for understanding neurochemical aberrations in the illness and suggest new approaches for pharmacological treatment. Propelled forward by rapid advances in neurochemical anatomy, current pathophysiological hypotheses of schizophrenia and antipsychotic drug action have taken on the appearance of complex electrical circuit diagrams. Second, molecular biology studies have now revealed that there is a multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong, D , D , and D ), some of which may become entirely new targets for 3 4 s antipsychotic drug action. Ironically, the development of drugs that are selec­ tive for these receptors and that can be used to investigate their function lags behind; yet the discovery of these new receptors offers unparalleled opportu­ nities for developing drugs with improved efficacy and fewer side effects.

Editors and Affiliations

  • Department of Psychiatry, Washington University, School of Medicine, St. Louis, USA

    John G. Csernansky

Bibliographic Information

  • Book Title: Antipsychotics

  • Editors: John G. Csernansky

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-61007-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-64653-9Published: 16 September 2011

  • eBook ISBN: 978-3-642-61007-3Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXV, 539

  • Number of Illustrations: 2 illustrations in colour

  • Topics: Pharmacology/Toxicology, Neurosciences

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